Results 151 to 160 of about 1,066,098 (345)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
NASA Proof-of-Concept 1-W(sub e) Stirling Convertor Development for Small Radioisotope Power Systems [PDF]
Low power Stirling convertors are being developed at NASA Glenn Research Center to provide future small spacecraft with electrical power by converting heat from one or more Light Weight Radioisotope Heater Units (LWRHU).
Casciani, Michael R. +3 more
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
An air-bearing weight offload system for ground test of heavy LSS structures [PDF]
The capability and use of the Gravity Offload Facility (GOF) are discussed. Briefly explained are the: truss and base casting; carriage assembly; carriage weldment; vertical lift axis control; lifting cylinder; payload gimbal; motion base layout; and ...
Rice, R. B.
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Jixie chuandong, 2010 2-D micro displacement worktable is designed based on two-planar four-bar linkage,which is sustained by internal and external double layer flexure hinge and is actuated by piezoelectricity ceramic actuator（PZT）.It has the advantage of simple structure ...
包丽雅 +3 more
doaj
QUASI-STATIC RESPONSE OF PLANAR PARALLEL-CONNECTION FLEXURE HINGES MECHANISM
, 2019 Published
Šalinić, Slaviša +1 more
openaire +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Development of compressor end seals stator interstage seals, and stator pivot seals in advanced air breathing propulsion systems. Part 1: Screening studies and analysis [PDF]
Design and characteristics of 28-inch diameter seals for air breathing propulsion systems - Part
Hawkins, R. M., Mckibbin, A. H.
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source