Results 41 to 50 of about 29,422 (236)

Aberrant Static and Dynamic Functional Network Connectivity in Heart Failure with Preserved Ejection Fraction

ESC Heart Failure, 2022
Abstract Aims Heart failure may lead to brain functional alterations related to cognitive impairment. This study aimed to detect alterations of static functional network connectivity (FNC) and dynamic FNC in heart failure with preserved ejection fraction (HFpEF) and to estimate the association ...
Liang Jiang, Shenghua Liu, Lin Li, Wen Wu, Zhongping Ai, Huiyou Chen, Xindao Yin, Yu‐Chen Chen   +7 more
openaire   +3 more sources

Alzheimer’s Disease Projection From Normal to Mild Dementia Reflected in Functional Network Connectivity: A Longitudinal Study

Frontiers in Neural Circuits, 2021
BackgroundAlzheimer’s disease (AD) is the most common age-related problem and progresses in different stages, including mild cognitive impairment (early stage), mild dementia (middle-stage), and severe dementia (late-stage). Recent studies showed changes
Mohammad S. E. Sendi, Mohammad S. E. Sendi, Mohammad S. E. Sendi, Elaheh Zendehrouh, Robyn L. Miller, Robyn L. Miller, Zening Fu, Yuhui Du, Yuhui Du, Jingyu Liu, Jingyu Liu, Elizabeth C. Mormino, Elizabeth C. Mormino, David H. Salat, David H. Salat, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun   +18 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Dynamic functional connectivity analysis reveals transient states of dysconnectivity in schizophrenia

NeuroImage: Clinical, 2014
Schizophrenia is a psychotic disorder characterized by functional dysconnectivity or abnormal integration between distant brain regions. Recent functional imaging studies have implicated large-scale thalamo-cortical connectivity as being disrupted in ...
E. Damaraju, E.A. Allen, A. Belger, J.M. Ford, S. McEwen, D.H. Mathalon, B.A. Mueller, G.D. Pearlson, S.G. Potkin, A. Preda, J.A. Turner, J.G. Vaidya, T.G. van Erp, V.D. Calhoun   +13 more
doaj   +1 more source

Examining Neural Connectivity in Schizophrenia Using Task-Based EEG: A Graph Theory Approach

Sensors, 2023
Schizophrenia (SZ) is a complex disorder characterized by a range of symptoms and behaviors that have significant consequences for individuals, families, and society in general. Electroencephalography (EEG) is a valuable tool for understanding the neural
Sergio Iglesias-Parro, María F. Soriano, Antonio J. Ibáñez-Molina, Ana V. Pérez-Matres, Juan Ruiz de Miras   +4 more
doaj   +1 more source

Static and dynamic brain functional connectivity patterns in patients with unilateral moderate-to-severe asymptomatic carotid stenosis

Frontiers in Aging Neuroscience
Background and purposeAsymptomatic carotid stenosis (ACS) is an independent risk factor for ischemic stroke and vascular cognitive impairment, affecting cognitive function across multiple domains.
Junjun Wang, Junjun Wang, Linfeng Song, Binlin Tian, Li Yang, Xiaoyu Gu, Xu Chen, Lei Gao, Lin Jiang   +8 more
doaj   +1 more source

Both Stationary and Dynamic Functional Interhemispheric Connectivity Are Strongly Associated With Performance on Cognitive Tests in Multiple Sclerosis

Frontiers in Neurology, 2020
Although functional connectivity has been extensively studied in MS, robust estimates of both stationary (static connectivity at the time) and dynamic (connectivity variation across time) functional connectivity has not been commonly evaluated and ...
Sue-Jin Lin, Shannon Kolind, Aiping Liu, Katrina McMullen, Irene Vavasour, Z. Jane Wang, Anthony Traboulsee, Martin J. McKeown, Martin J. McKeown   +8 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source