Results 31 to 40 of about 64,439 (239)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Advances in Mechanical Engineering, 2016 Using theoretical modeling combined with monitoring data, the typical dynamic and static behaviors of a continuous steel truss arch railway bridge are evaluated.
Yong-sheng Song +5 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Method for lateral forces in stability analysis of concave slopes in plan view
Yantu gongcheng xuebao, 2018 Although it is well known that the stability of concave slopes in plan view is better than that of straight slopes, it is difficult to accurately calculate the factor of safety of concave slopes because the lateral forces perpendicular to the sliding ...
LI Li 1, LIU Zi-ru 2
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Slope protection using geosynthetic materials - a case study on the graveyard complex of mataram royal king [PDF]
E3S Web of ConferencesThis paper presents the study case of landslide occurred at the Imogiri Cemetery, Mataram Royal Kings Graveyard Complex. On March 17, 2019, a landslide occurred, it was expected to have been triggered by heavy rainfall of 148 mm/day intensity.
Nurjannah Dhinta Ayundya +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Natural Hazards ResearchDam failure can occur due to foundation instability, downstream and upstream slopes instabilities. This study assesses the stability of upstream and downstream slope cuts at Khalid-Dijo irrigation dam project, which is located in Southern Ethiopia, 3 km
Demeke Wendim, Mamaru Genetu
doaj +1 more source