Results 41 to 50 of about 64,439 (239)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Features of geotechnical testing of square section piles in seasonally frozen soils

Smart Construction and Sustainable Cities
This study compares the bearing capacity results of piles obtained through static and dynamic load tests, using different safety factors. The Static Load Test (SLT) based on GOST standards indicated a bearing capacity of 1400 kN.
Askar Zhussupbekov, Abdulla Omarov, Ainur Montayeva   +2 more
doaj   +1 more source

Performance analysis on the structure of the bracket mounting for hybrid converter kit: Finite-element approach

Curved and Layered Structures, 2023
An electric motor mounting bracket is used in electric vehicles, especially hybrid ones using a parallel hybrid configuration. This study aims to analyze the strength and performance of the initial design and topology optimized design.
Effendi Ma’ruf Yanuar, Ubaidillah Ubaidillah, Budiana Eko Prasetya, Lenggana Bhre Wangsa   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Static stress and fatigue life analysis of rocket trolley leaf spring using numerical simulation [PDF]

MATEC Web of Conferences
A rocket trolley is an equipment used to transport or move rockets from one place to another. A leaf spring is one of the essentials of a rocket trolley.
Wibawa Lasinta Ari Nendra, Ibadi Mahfud, Purnomo Herry   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Hybrid Bearings Static Load Capacity and Its Application

Tribology Online
The static load rating of hybrid bearings is a performance parameter used in designing hybrid bearings applications. The calculation of this load capacity factor is specified by the International Standard ISO 20056-2:2017.
Alexander R. Gabelli
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Structural performance evaluation of electric vehicle chassis under static and dynamic loads

Scientific Reports
Electric vehicle (EV) production is pivotal in achieving environmental sustainability by reducing greenhouse gas emissions and air pollution. Since the weight of electric vehicles directly influences the energy consumption and driving range of the ...
Omar Zamzam, Aly A. Ramzy, Mohamed Abdelaziz, Tamer Elnady, Ayman A. Abd El-Wahab   +4 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source