Results 41 to 50 of about 369 (262)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

THE EVALUATION OF THE EFFECT OF REACTIVE POWER COMPENSATION IN ELECTRIC POWER LOSSES IN ELECTRIC NETWORK OF RAILWAY JUNCTION

Nauka ta progres transportu, 2009
In this work the generalized mathematical model of an electrical network of the electrified railway junction is proposed. An estimation of influence of static var compensators installation on electric power losses in a network is executed on the basis of
O. I. Bondar, I. L. Bondar
doaj  

Coordinated Volt/VAR Control in Distribution Networks Considering Demand Response via Safe Deep Reinforcement Learning

Energies
Volt–VAR control (VVC) is essential in maintaining voltage stability and operational efficiency in distribution networks, particularly with the increasing integration of distributed energy resources. Traditional methods often struggle to manage real-time
Dong Hua, Fei Peng, Suisheng Liu, Qinglin Lin, Jiahui Fan, Qian Li   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Adaptive Wide-Area Control of Power Systems Through Dynamic Load Modulating SVCs

IEEE Access, 2022
This paper presents an adaptive wide-area control strategy based on energy function. The proposed method enhances the post-fault oscillation damping capability of Static Var Compensators (SVC) by incorporating load dynamics in the wide-area controller ...
Amin Sharafi, Arash Vahidnia, Mahdi Jalili, Gerard Ledwich   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Application of SVC on Damping Subsynchronous Oscillations in Power Systems

Kongzhi Yu Xinxi Jishu, 2011
Applying static var compensators (SVC) connecting with 500 kV bus of power plant through 500 kV/35 kV starting up stand by transformer, completing SVC susceptance modulation var speed deviation feedback of generator’s shaft system, and adopting SVC main ...
武云生, 卓华
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Enhanced performance of substation dynamics during large induction motor starting using SVC

Alexandria Engineering Journal, 2018
Static Var Compensators (SVC) have been widely used to separately improve each of voltage variation performance and steady state power factor of industrial substations. However, these two functions are interdependent, power factor improvement tends to do
Ahmed S. Omran, Nabil H. Abbasy, Ragi A. Hamdy   +2 more
doaj   +1 more source

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein, Scott Moerdler, Alexander A. Boucher, Stacy L. Cooper, Rachel A Egler, Erika Friehling, Richard Ho, Catherine McGuinn, Kathryn S. Sutton, Stacey G. Zahler, Leslie Kersun, Jennifer Kesselheim   +11 more
wiley   +1 more source