Results 41 to 50 of about 4,554 (306)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Optimization of the thyristor valves design for TCR static VAR compensators [PDF]

, 1991
Describes a program developed to optimize the design of thyristor valves for Static VAR Compensators (SVC) of the Thysristor Controlled Reactors (TCR ...
Afonso, João L., Freire, A. R. F., Lima, A. G. G., Soares, G. A.   +3 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Cyber-Physical Distribution Systems Resilience Against Cyberattacks via a Remediation Framework Based on Static VAR Compensators (SVCs)

IEEE Access
This paper proposes a framework to optimally employ static VAR compensators (SVCs) within a customized reconfiguration of system topology, leading to remediation of voltage violations caused by false data injection (FDI) cyberattacks targeting smart ...
Ehsan Naderi, Arash Asrari
doaj   +1 more source

A Hybrid Approach for Power System Security Enhancement via Optimal Installation of Flexible AC Transmission System (FACTS) Devices

Energies, 2017
Increasing demand for electricity has placed heavy stress on power system security. Therefore, this paper focuses on the problem of how to maximize power system static security in terms of branch loading and voltage level under normal operation and even ...
Tong Kang, Jiangang Yao, ThanhLong Duong, Shengjie Yang, Xiangqian Zhu   +4 more
doaj   +1 more source

Unstationnary control of a launcher using observer-based structures [PDF]

, 2003
This paper deals with the design of a gain-scheduled controller for the attitude control of a launcher during atmospheric flight. The design is characterized by classical requirements such as phase/gain margins and flexible mode attenuations as well as
Alazard, Daniel, Clément, Benoît, Voinot, Olivier   +2 more
core  

A pricing mechanism for network reactive power devices in competitive market [PDF]

, 2005
In this paper, a pricing mechanism is proposed for network reactive power compensation devices in competitive markets. The cost components of network devices are examined in the paper.
Zhong, J
core   +1 more source

Balancing asymmetrical load using a static var compensator [PDF]

IEEE PES Innovative Smart Grid Technologies, Europe, 2014
Power electronic controllers are employed in the transmission and distribution levels of the power systems. In transmission level applications, Flexible AC Transmission System (FACTS) controllers, consist of shunt and series static compensators, are applied for power flow control, stability enhancement, voltage regulation and power oscillation damping.
Alsulami, Amar, Bongiorno, Massimo, Srivastava, Kailash, Reza, Muhammad   +3 more
openaire   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

New trends in active filters for improving power quality [PDF]

, 1995
Since their basic compensation principles were proposed around 1970, active filters have been studied by many researchers and engineers aiming to put them into practical applications.
Akagi, Hirofumi
core   +1 more source