Results 41 to 50 of about 1,326 (292)

A Hybrid Approach for Power System Security Enhancement via Optimal Installation of Flexible AC Transmission System (FACTS) Devices

Energies, 2017
Increasing demand for electricity has placed heavy stress on power system security. Therefore, this paper focuses on the problem of how to maximize power system static security in terms of branch loading and voltage level under normal operation and even ...
Tong Kang, Jiangang Yao, ThanhLong Duong, Shengjie Yang, Xiangqian Zhu   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

THE EVALUATION OF THE EFFECT OF REACTIVE POWER COMPENSATION IN ELECTRIC POWER LOSSES IN ELECTRIC NETWORK OF RAILWAY JUNCTION

Nauka ta progres transportu, 2009
In this work the generalized mathematical model of an electrical network of the electrified railway junction is proposed. An estimation of influence of static var compensators installation on electric power losses in a network is executed on the basis of
O. I. Bondar, I. L. Bondar
doaj  

Coordinated Volt/VAR Control in Distribution Networks Considering Demand Response via Safe Deep Reinforcement Learning

Energies
Volt–VAR control (VVC) is essential in maintaining voltage stability and operational efficiency in distribution networks, particularly with the increasing integration of distributed energy resources. Traditional methods often struggle to manage real-time
Dong Hua, Fei Peng, Suisheng Liu, Qinglin Lin, Jiahui Fan, Qian Li   +5 more
doaj   +1 more source

Adaptive Wide-Area Control of Power Systems Through Dynamic Load Modulating SVCs

IEEE Access, 2022
This paper presents an adaptive wide-area control strategy based on energy function. The proposed method enhances the post-fault oscillation damping capability of Static Var Compensators (SVC) by incorporating load dynamics in the wide-area controller ...
Amin Sharafi, Arash Vahidnia, Mahdi Jalili, Gerard Ledwich   +3 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Application of SVC on Damping Subsynchronous Oscillations in Power Systems

Kongzhi Yu Xinxi Jishu, 2011
Applying static var compensators (SVC) connecting with 500 kV bus of power plant through 500 kV/35 kV starting up stand by transformer, completing SVC susceptance modulation var speed deviation feedback of generator’s shaft system, and adopting SVC main ...
武云生, 卓华
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