Results 111 to 120 of about 22,583 (293)
Integrative Approaches to Treating Cellular Senescence in Kidney Disease
Advanced Science, EarlyView.ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa +3 more
wiley +1 more source
Croatian Journal of Philosophy, 2020 Can statism help with burning issues of the present time? The authors in the collection mostly answer affirmatively; in their view, states can successfully deal with their cosmopolitan responsibilities. In the discussion, we question this optimistic assumption and suggest the need for a more supra-statist, cosmopolitan arrangement for solving the ...
openaire +1 more source
Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Advanced Science, EarlyView.Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source
Neoliberal Ideology in France: A Qualitative Inquiry. [PDF]
Front Psychol, 2021 Girerd L, Verniers C, Bonnot V.
europepmc +1 more source
Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes
Advanced Science, EarlyView.Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang +14 more
wiley +1 more source
How Neoliberal are You? Development and Validation of the Neoliberal Orientation Questionnaire. [PDF]
Int Rev Soc Psychol, 2023 Girerd L, Jost JT, Bonnot V.
europepmc +1 more source
Advanced Science, EarlyView.Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu +11 more
wiley +1 more source
The State and the Citizen: Overview of a complex relationship from a paradigmatic perspective. [PDF]
Qual Quant, 2023 Voinea CF, Neumann M, Troitzsch KG.
europepmc +1 more source
Advanced Science, EarlyView.We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang +14 more
wiley +1 more source