Results 81 to 90 of about 2,833 (266)

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Law-Making Regulated by Law in Ukraine

Bulletin of Kharkiv National University of Internal Affairs
The article traces the main directions of the transition in theoretical discourse on law-making from the Soviet era to the present day, highlighting the historical and methodological foundations of its development. It demonstrates that as a phenomenon of
V. Ye. Kyrychenko
doaj   +1 more source

Globalization and governance: from statism to polycentrism [PDF]

, 2004
This paper explores the implications of globalization for governance. It argues that the contemporary large-scale and accelerated growth of transworld connectivity has rendered the statist mode of governance unviable and encouraged the emergence of ...
Scholte, Jan Aart, Jan Aart Scholte
core   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

The Fabian Debate and the Sources of Michael Young’s The Rise of Meritocracy

Scienza & Politica
The essay aims to reconstruct the theoretical-political premises of The Rise of Meritocracy (1958) by Michael Young and his criticism of Labour dirigism and the English school system of the time.
Salvatore Cingari
doaj   +1 more source

Fallen Behind: Science, Technology and Soviet Statism [PDF]

, 2015
Why, despite the overwhelming enthusiasm from the state for science and technology, did the Soviet Union fail in its project of modernization? This essay argues that the fundamental reason behind the Soviet Union\u27s technological lag, and its ...
Chan, Chi Ling
core  

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

O estatismo: subjetividade e espaço nos «Três Contos», de Flaubert

Caligrama: Revista de Estudos Românicos, 2012
Resumo: Enunciado originalmente por Lukács, o termo estatismo relaciona-se a procedimentos narrativos observados na vanguarda literária. Este texto tem o objetivo de utilizar tal nomenclatura como um conceito-chave para a compreensão dos Três contos, de ...
Maria Elvira Malaquias de Carvalho
doaj   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

Expanding Statism through Sovereign Investment? Evidence from the Domestic-Focused Indonesia Investment Authority

Jurnal Hubungan Internasional
This study examined Indonesia’s first-ever sovereign wealth fund (SWF), known as the Indonesia Investment Authority (INA), focusing on domestic investment.
Raras Cahyafitri
doaj   +1 more source