Results 101 to 110 of about 7,745,200 (298)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Evaluation of prognostic models to improve prediction of metastasis in patients following potentially curative treatment for primary colorectal cancer: the PROSPECT trial

Health Technology Assessment
Background Despite apparently curative treatment, many patients with colorectal cancer develop subsequent metastatic disease. Current prognostic models are criticised because they are based on standard staging and omit novel biomarkers.
Vicky Goh, Susan Mallett, Manuel Rodriguez-Justo, Victor Boulter, Rob Glynne-Jones, Saif Khan, Sarah Lessels, Dominic Patel, Davide Prezzi, Stuart Taylor, Steve Halligan   +10 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Tutorial on Bonferroni Correction as a Post Hoc Analysis of a Significant Chi-Squared Test: A Methodological Guide in Food Science [PDF]

Journal of Food Quality and Hazards Control
Background: In medical research, analyzing the relationship between two categorical variables is common. While chi-square tests (e.g., Pearson's, McNemar's, and Cochran-Mantel-Haenszel) can determine if a significant association exists, they do not ...
F. Madadizadeh, M. Abdoli
doaj  

Statistical Policy Working Paper 16. A Comparative Study of Reporting Units in Selected Employer Data Systems

The Employer Reporting Unit Match Study (ERUMS) was a pilot record linkage study carried out under the auspices of the Federal Committee on Statistical Methodology (FCSM), Office of Management and Budget.
United States. Federal Committee on Statistical Methodology
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Journal of the Statistical Society.

Mode of access: Internet.Vols. 36-50, 1873-87. 1 v.
Statistical Society (Great Britain)
core  

LISA: Virginia Tech's Laboratory for Interdisciplinary Statistical Analysis Annual Report 2014-15

, 2016
The 2014-15 academic year was very successful for LISA, Virginia Tech’s Laboratory for Interdisciplinary Statistical Analysis. LISA statistical collaborators helped 1349 researchers around Virginia Tech for the three main services of Collaboration ...
Vance, Eric A., Pruitt, Tonya
core  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Synergy and Attenuation of Work-Related Factors in Musculoskeletal Disorders: The Combined Risk Based on Data from the Korean Working Conditions Survey

Medicina
Background and objectives: Musculoskeletal disorders (MSDs) account for more than 60% of compensated occupational diseases in Korea. Despite this burden, benchmarks of standardized ergonomic exposure and evidence on the combined effects of risk factors ...
Eun-Soo Lee, Myong-Hwan Kim, Dongmug Kang, Youn-Hyang Lee, Yoon-Ji Kim, Se-Yeong Kim, Youngki Kim   +6 more
doaj   +1 more source