Results 271 to 280 of about 17,333,893 (364)
Model behavior: fixed ideas, random thoughts - rethinking model selection in meta-analysis. [PDF]
Choi GJ, Kang H.
europepmc +1 more source
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo+6 more
wiley +1 more source
Variable expression of hepatic genes in different liver tumor cell lines: conclusions for drug testing. [PDF]
Wisniewska MJ+7 more
europepmc +1 more source
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié+16 more
wiley +1 more source
Disparity between statistical significance and clinical importance in published randomised controlled trials: a methodological study. [PDF]
Esterhuizen TM+7 more
europepmc +1 more source
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker+16 more
wiley +1 more source
Oncogenic Role and Drug Resistance Effect of CCDC6 in iCCA: Potential Strategies for Targeted Intervention. [PDF]
Chen J+10 more
europepmc +1 more source
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad+17 more
wiley +1 more source
Antiarrhythmic Effects of Supercritical Extract of <i>Acmella oleracea</i> in Rats: Electrophysiological Evidence and Cardioprotective Potential. [PDF]
de Souza E Silva AP+10 more
europepmc +1 more source
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande+11 more
wiley +1 more source