Results 51 to 60 of about 13,417,468 (277)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Identifying Functional Mechanisms in Psychotherapy: A Scoping Systematic Review
Frontiers in Psychiatry, 2020 The identification of fundamental mechanisms is an important scientific pursuit in many fields of enquiry. With regard to the development of psychological treatments, understanding the mechanisms through which change occurs such that psychological ...
Timothy A. Carey +4 more
doaj +1 more source
, 2017 We give complete algorithms and source code for constructing statistical risk models, including methods for fixing the number of risk factors. One such method is based on eRank (effective rank) and yields results similar to (and further validates) the ...
Kakushadze, Zura, Yu, Willie
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Discriminatory Accuracy of the Gail Model for Breast Cancer Risk Assessment among Iranian Women
Iranian Journal of Public Health, 2020 Background: The Gail model is the most well-known tool for breast cancer risk assessment worldwide. Although it was validated in various Western populations, inconsistent results were reported from Asian populations.
Sahar ROSTAMI +5 more
doaj +1 more source
Statistical Procedures and Robust Statistics [PDF]
, 2002 It is argued that a main aim of statistics is to produce statistical procedures which in this article are defined as algorithms with inputs and outputs. The structure and properties of such procedures are investigated with special reference to topological and testing considerations.
openaire +4 more sources
EMBO reports, 2012 Appropriate statistical analysis is vital to the integrity of the scientific record, but experience and intuition also play a role in interpreting results. Scientific progress should not be hampered through statistical over‐evaluation.
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Issues in Statistical Inference [PDF]
, 2002 The APA Task Force’s treatment of research methods is critically examined. The present defense of the experiment rests on showing that (a) the control group cannot be replaced by the contrast group, (b) experimental psychologists have valid reasons to ...
Chow, Dr. Siu L.
core
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source