Results 61 to 70 of about 13,417,468 (277)

Skepticism and pharmacophobia toward medication may negatively impact adherence to psychiatric medications: a comparison among outpatient samples recruited in Spain, Argentina, and Venezuela

Patient Preference and Adherence, 2018
Carlos De las Cuevas,1 Mariano Motuca,2 Trino Baptista,3 Jose de Leon4–6 1Department of Internal Medicine, Dermatology and Psychiatry, Universidad de La Laguna, Canary Islands, Spain; 2Instituto Vilapriño, Center for Studies, Assistance and
De las Cuevas C, Motuca M, Baptista T, de Leon J   +3 more
doaj  

Application of engineering statistical methods with the aim to increase service and product quality [PDF]

Tehnika
With the aim of increasing the quality of the service or product, it is possible to apply different statistical methods. The application of engineering statistical methods for this purpose refers to the processing of data that can be collected in ...
Vasiljević Saša Ž., Rajković Dragan D., Tanasković Aleksandra A.   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Statistical inference using SGD

, 2017
We present a novel method for frequentist statistical inference in $M$-estimation problems, based on stochastic gradient descent (SGD) with a fixed step size: we demonstrate that the average of such SGD sequences can be used for statistical inference ...
Caramanis, Constantine, Kyrillidis, Anastasios, Li, Tianyang, Liu, Liu   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Statistical Physics of Structural Glasses

, 2000
This paper gives an introduction and brief overview of some of our recent work on the equilibrium thermodynamics of glasses. We have focused onto first principle computations in simple fragile glasses, starting from the two body interatomic potential.
, , , , , , , , , , Adams G, Angelani L, Angell C A, Barrat J-L, Bouchaud J-P, Büchner S, Cardenas M, Cavagna A, Chandra P, Coluzzi B, Coluzzi B, Coluzzi B, Crisanti A, De Benedetti P, Franz S, Franz S, Franz S, Gibbs J H, Giorgio Parisi, Goldbart P M, Goldstein M, Hansen J-P, Jäckle J, Kauzman A W, Kirkpatrick T R, Kob W, Marc Mézard, Marinari E, Marinari E, Marinari E, Mézard M, Mézard M, Parisi G, Sciortino F, Sciortino F, Sciortino F, Speedy R J, Stillinger F H   +47 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gamma-ray Burst Formation Environment: Comparison of Redshift Distributions of GRB Afterglows [PDF]

Journal of Astronomy and Space Sciences, 2005
Since gamma-ray bursts(GRBs) have been first known to science societites in 1973, many scientists are involved in their studies. Observations of GRB afterglows provide us with much information on the environment in which the observed GRBs are born. Study
Sung-Eun Kim, Heon-Young Chang
doaj   +1 more source

Quantum Chaos and Statistical Mechanics

, 1994
We briefly review the well known connection between classical chaos and classical statistical mechanics, and the recently discovered connection between quantum chaos and quantum statistical mechanics.Comment: talk given at the Conference on Fundamental ...
Berry, Berry, Berry, Sinai, Srednicki
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source