Results 71 to 80 of about 13,417,468 (277)

Statistical Physics of Self-Replication

, 2012
Self-replication is a capacity common to every species of living thing, and simple physical intuition dictates that such a process must invariably be fueled by the production of entropy. Here, we undertake to make this intuition rigorous and quantitative
Gardiner C. W., Jeremy L. England, Neidhardt F. C., Rothbaum H. P.   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Real-Time Statistical Speech Translation

, 2014
This research investigates the Statistical Machine Translation approaches to translate speech in real time automatically. Such systems can be used in a pipeline with speech recognition and synthesis software in order to produce a real-time voice ...
A. Radziszewski, D. Cer, F. Holz
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Factors influencing adherence to psychopharmacological medications in psychiatric patients: a structural equation modeling approach

Patient Preference and Adherence, 2017
Carlos De las Cuevas,1 Jose de Leon,2–4 Wenceslao Peñate,5 Moisés Betancort5 1Departamento de Medicina Interna, Dermatología y Psiquiatría, Universidad de La Laguna, Canary Islands, Spain; 2Mental Health Research Center
De las Cuevas C, de Leon J, Peñate W, Betancort M   +3 more
doaj  

Statistical Physics in Meteorology

, 2004
Various aspects of modern statistical physics and meteorology can be tied together. The historical importance of the University of Wroclaw in the field of meteorology is first pointed out.
Andrade, Andrews, Anthens, Ausloos, Benzi, Bretherton, Brockwell, Cahalan, Cahalan, Davis, Davis, Davis, Davis, Driedonks, Fraedrich, Garratt, Gerber, Hasselmann, Ivanova, Ivanova, Ivanova, Ivanova, Ivanova, Ivanova, Ivanova, Ivanova, Karner, Kiang, Kitova, Kitova, Koscielny-Bunde, Koscielny-Bunde, Liljegren, Lorenz, Lovejoy, Lovejoy, M Ausloos, Malamud, Marshak, Maurellis, Miranda, Miranda, Molteni, Monetti, Monmonier, Neggers, Neto, O'Connel, Ou, Palmer, Pasini, Pelletier, Pinho, Rees, Rodts, Rogers, Rosenfeld, Roux, Salisbury, Santhanam, Schertzer, Schreiber, Sreenivasan, Stokes, Talkner, Tessier, Tsonis, Tsonis, Velho, Westwater, Westwater   +70 more
core   +1 more source

The Statistics of q-Statistics

Entropy
Almost two decades ago, Ernesto P. Borges and Bruce M. Boghosian embarked on the intricate task of composing a manuscript to honor the profound contributions of Constantino Tsallis to the realm of statistical physics, coupled with a concise exploration of q-Statistics.
Deniz Eroglu, Bruce M. Boghosian, Ernesto P. Borges, Ugur Tirnakli   +3 more
openaire   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source