Results 91 to 100 of about 11,222,791 (325)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Statistical Analysis and Parameter Selection for Mapper [PDF]

, 2017
In this article, we study the question of the statistical convergence of the 1-dimensional Mapper to its continuous analogue, the Reeb graph. We show that the Mapper is an optimal estimator of the Reeb graph, which gives, as a byproduct, a method to ...
Carrière, Mathieu, Michel, Bertrand, Oudot, Steve   +2 more
core   +2 more sources

A Mizuno-Todd-Ye predictor-corrector infeasible-interior-point method for symmetric optimization with the arc-search strategy

Journal of Inequalities and Applications, 2017
In this paper, we propose a Mizuno-Todd-Ye predictor-corrector infeasible-interior-point method for symmetric optimization using the arc-search strategy.
Ximei Yang, Yinkui Zhang
doaj   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Statistical analysis of the equivalent design rainfall [PDF]

, 2005
Statistical analyses of rainfall data are used for the design of sewerage systems and pump-stations, for the evaluation of the duration and the frequency of overflow in runoff detention facilities, for the determination of the critical influence on a ...
Bogataj, Marija, Kompare, Boris, Panjan, Jože   +2 more
core  

Development of New Predictive Equations for the Resting Metabolic Rate (RMR) of Women with Lipedema

Metabolites
This study aimed to develop a novel predictive equation for calculating resting metabolic rate (RMR) in women with lipedema. We recruited 119 women diagnosed with lipedema from the Angiology Outpatient Clinic at Wroclaw Medical University, Poland.
Małgorzata Jeziorek, Jakub Wronowicz, Łucja Janek, Krzysztof Kujawa, Andrzej Szuba   +4 more
doaj   +1 more source

Radial Symmetry and Monotonicity of Solutions to a System Involving Fractional p-Laplacian in a Ball

Advances in Mathematical Physics, 2018
In this paper, we study a nonlinear system involving the fractional p-Laplacian in a unit ball and establish the radial symmetry and monotonicity of its positive solutions. By using the direct method of moving planes, we prove the following result.
Linfen Cao, Xiaoshan Wang, Zhaohui Dai
doaj   +1 more source

Evolution of a geometric constant along the Ricci flow

Journal of Inequalities and Applications, 2016
In this paper, we establish the first variation formula of the lowest constant λ a b ( g ) $\lambda_{a}^{b}(g)$ along the Ricci flow and the normalized Ricci flow, such that to the following nonlinear equation there exist positive solutions: − Δ u + a u ...
Guangyue Huang, Zhi Li
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source