Results 71 to 80 of about 29,239,112 (356)

The 2-good-neighbour diagnosability of modified bubble-sort graphs under the PMC and MM* model

Systems Science & Control Engineering, 2020
The study of interconnection networks is a hot topic for multiprocessor systems. Diagnosability plays an important role in the study of interconnection networks. A new measure for fault diagnosis of a system is proposed by Peng et al. in 2012.
Yanling Wang, Shiying Wang
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Spatial patterns of fertilizer use and imbalances: Evidence from rice cultivation in India

Environmental Challenges, 2022
Fertilizer use immensely contributes to sustaining higher crop productivity and ensuring food security around the globe. However, the over-application of nitrogenous fertilizers resulted in negative environmental externalities. Thus, assessing imbalances
Kaushik Bora
doaj  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies

Scientific Reports, 2017
Single nucleotide variants (SNVs) identified in cancer genomes can be de-convolved using non-negative matrix factorization (NMF) into discrete trinucleotide-based mutational signatures indicative of specific cancer-causing processes. The stability of NMF-
Philip R. Davidson, Amy L. Sherborne, Barry Taylor, Alice O. Nakamura, Jean L. Nakamura   +4 more
doaj   +1 more source

Statistical Analysis of Metagenomics Data

Genomics & Informatics, 2019
Understanding the role of the microbiome in human health and how it can be modulated is becoming increasingly relevant for preventive medicine and for the medical management of chronic diseases.
M. Calle
semanticscholar   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

The evaluation and optimization of the agricultural sustainable development based on a data-driven approach: A case from Northern Anhui

Heliyon
The sustainable advancement of agriculture stands as the fundamental cornerstone of sustainable human progress. This study introduces a data-centric methodological framework founded upon the holistic delineation of measurement, feature assessment, and ...
Fengwei Gao, Zhuangzhuang Li, Pei Zhang, Yimin Wu   +3 more
doaj  

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Evolution of a geometric constant along the Ricci flow

Journal of Inequalities and Applications, 2016
In this paper, we establish the first variation formula of the lowest constant λ a b ( g ) $\lambda_{a}^{b}(g)$ along the Ricci flow and the normalized Ricci flow, such that to the following nonlinear equation there exist positive solutions: − Δ u + a u ...
Guangyue Huang, Zhi Li
doaj   +1 more source