Results 101 to 110 of about 356,980 (295)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Simulation and optimization of hydraulic fracturing in deep coal-rock reservoirs [PDF]

AIP Advances
Deep coalbed methane (CBM) reservoirs represent a promising yet technically challenging frontier in unconventional gas development, owing to their ultra-low permeability, pronounced heterogeneity, and complex in situ stress conditions.
Xiaoyong Wen, Qian Liu, Yi Zhang, Qianyun Zhao, Lishijia Han, Jinghong Hu   +5 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Brain-derived neurotrophic factor/FK506-binding protein 5 genotype by childhood trauma interactions do not impact on hippocampal volume and cognitive performance.

PLoS ONE, 2014
In the development of psychotic symptoms, environmental and genetic factors may both play a role. The reported association between childhood trauma and psychotic symptoms could therefore be moderated by single nucleotide polymorphisms (SNPs) associated ...
Dennis Hernaus, Ruud van Winkel, Ed Gronenschild, Petra Habets, Gunter Kenis, Machteld Marcelis, Jim van Os, Inez Myin-Germeys, Dina Collip, for Genetic Risk and Outcome in Psychosis (G.R.O.U.P.)   +9 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Commentary: Structural equation models and causal claims in soil science and biogeochemistry – An equation-free “how to”

Geoderma
Structural equation modeling (SEM) is a set of approaches that have seen exponential usage in the soil sciences as well as the related fields of agriculture and biogeochemistry. When correctly used and interpreted, SEM can be a powerful and flexible tool
Jordon Wade, Teal M. Potter, Andrew J. Margenot   +2 more
doaj   +1 more source

Response-Surface Methods in R, Using rsm [PDF]

This article describes the recent package rsm, which was designed to provide R support for standard response-surface methods. Functions are provided to generate central-composite and Box-Behnken designs.
Russell V. Lenth
core   +1 more source

STATISTICAL DESIGN METHOD ABOUT WEIGHT AND CONSTRUCTION WIDTH OF ANTI-SCOUR BLOCK WORK AROUND PIER PROTECTION

Doboku Gakkai Ronbunshu, 1990
The stability of concrete-block work for the protection of the pier against the scour at flood is discussed by the way of the multivariate analysis.By using the data on the safety blocks and the flow-out blocks at flood-time, the discriminant analysis is executed.In conseqence, the discriminant function for the stability with the six variables is ...
Katsuya OKADA, Masaki SEKI, Hisashi MURAISHI, Tsuyoshi KAJIMA   +3 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Confounding of linkage disequilibrium patterns in large scale DNA based gene-gene interaction studies

BioData Mining, 2019
Background In Genome-Wide Association Studies (GWAS), the concept of linkage disequilibrium is important as it allows identifying genetic markers that tag the actual causal variants.
Marc Joiret, Jestinah M. Mahachie John, Elena S. Gusareva, Kristel Van Steen   +3 more
doaj   +1 more source