Results 21 to 30 of about 5,575,505 (199)

Deep learning-based ranking method for subgroup and predictive biomarker identification in patients

Communications Medicine
Background The task of identifying patient subgroups with enhanced treatment responses is important for clinical drug development. However, existing deep learning-based approaches often struggle to provide clear biological insights.
Zihuan Liu, Yihua Gu, Xin Huang
doaj   +1 more source

Adaptive Differential Privacy Cox-MLP Model Based on Federated Learning

Mathematics
In the data-driven healthcare sector, balancing privacy protection and model performance is critical. This paper enhances accuracy and reliability in survival analysis by integrating differential privacy, deep learning, and the Cox proportional hazards ...
Jie Niu, Runqi He, Qiyao Zhou, Wenjing Li, Ruxian Jiang, Huimin Li, Dan Chen   +6 more
doaj   +1 more source

The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Combined oral contraceptive (COC) use in obese adult women dramatically increases the relative risk of developing a pulmonary embolism (PE). The risk of a PE in obese adolescent females taking contraceptives is currently unknown. The purpose of this investigation was to determine the effect of body mass index (BMI) and contraceptive
John Puetz, Joanne Salas
wiley   +1 more source

Incorporating human dynamic populations in models of infectious disease transmission: a systematic review

BMC Infectious Diseases, 2022
Background An increasing number of infectious disease models consider demographic change in the host population, but the demographic methods and assumptions vary considerably.
Signe Møgelmose, Karel Neels, Niel Hens
doaj   +1 more source

Well-being horizons for silver and golden ages: an application of traditional and fuzzy Markov chains

Humanities & Social Sciences Communications
European societies are currently in a process of population ageing. Although this is the general trend, it would be desirable to know whether the characteristics and intensity of this ageing process are homogeneous in all European countries. In this work,
Qi Guo, Irene Albarrán, Pablo J. Alonso-González, Aurea Grané   +3 more
doaj   +1 more source

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source

Feasibility and Safety of Somato‐Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi, Takashi Matsuzawa, Jun Yamanishi, Masahiro Yoshitomi, Junji Ikeda, Shin‐Ichi Tsujimoto, Yasuteru Yamaguchi, Norio Shiba, Dhroov Pathare, Ayumi Kato, Masahiko Hara   +10 more
wiley   +1 more source

Sex Differences in Depression and Sleep Disturbance as Inter-Related Risk Factors of Diabetes

Frontiers in Clinical Diabetes and Healthcare, 2022
ObjectivesPrevious studies identified depression and sleep disturbance as risk factors for diabetes. Sleep disturbance and depression are known to be inter-related. Further, women relative to men are more prone to depression.
Clara S. Li, Rose Porta, Shefali Chaudhary   +2 more
doaj   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source