Results 121 to 130 of about 1,796,099 (244)

Statistical interpretation of medical data of patients with alcohol abuse

Open Medicine, 2012
Bardarov Ventzislav, Simeonova Pavlina, Neikova Ludmila, Bardarov Krum, Simeonov Vasil, Tsakovski Stefan, Kanev Kamen   +6 more
doaj   +1 more source

BILBO: a self-hosted platform for large-scale RNA-Seq analysis with a functional annotation clustering framework. [PDF]

Funct Integr Genomics
da Silva VLC, Alvarenga JVR, Linhares-Neto MV, Noman M, Chalfun-Junior A.   +4 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Governing accelerated evidence in real-time clinical trials. [PDF]

Commun Med (Lond)
Seixas AA.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Methodological considerations regarding propofol versus sevoflurane induction in patients with mitral stenosis. [PDF]

Braz J Anesthesiol
Ejaz A.
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Impact of direct transfer to critical care on mortality for patients who undergo emergency colorectal cancer resection: a national population-based cohort study in England. [PDF]

BJA Open
Blake HA, Rashid A, Watton L, Kuryba A, Boyle JM, Vallance A, Berkman L, Harrison DA, Doidge J, Moonesinghe SR, Murray D, Hill J, Fearnhead NS, van der Meulen J, Sharples LD, Walker K.   +15 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Explainable machine learning framework with Granger-based temporal predictive validation for monitoring fiscal risk in national health insurance expenditure. [PDF]

PLoS One
Lee G.
europepmc   +1 more source