Results 101 to 110 of about 27,685,557 (280)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Análise rotineira de dados de vigilância em saúde pública: que procedimentos estatísticos utilizar?

Revista de Saúde Pública
Tem havido no país, nos últimos anos, crescente interesse por questões vinculadas à área tradicionalmente denominada vigilância epidemiológica (que se denominou vigilância em saúde pública). Tem-se defendido, em muitas publicações, o ponto de vista que o
Odécio Sanches
doaj  

Usefulness of statistical implicative analysis to identify prognostic factors in patients with breast cancer

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2019
Background: identifying prognostic factors in patients with breast cancer continues to be a necessity.Objective: to assess the usefulness of statistical implicative analysis to identify the prognostic factors which contribute to the progress of the ...
Surama Pardo-Santana, Nelsa María Sagaró-del-Campo, Larisa Zamora-Matamoros, Dulce María Viltre-Castellanos   +3 more
doaj  

After all, what is the proper use of Kappa statistics in oral health surveys? What don’t manuals tell us?

Brazilian Oral Research
The aim of this study was to elucidate, unclear points of the “Oral Health Survey: basic methods”, of the World Health Organization (WHO), relative to reproducibility (encompassed reliability and agreement) issues during examiners’ calibration.
Andréa Videira ASSAF, Renato Pereira da Silva, Fábio Luiz Mialhe, Antonio Carlos Pereira   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Analyzing Gensini Score as a Semi-Continuous Outcome

Journal of Tehran University Heart Center, 2016
Background: Investigators frequently encounter continuous outcomes with plenty of values clumped at zero called semi-continuous outcomes. The Gensini score, one of the most widely used scoring systems for expressing coronary angiographic results, is of ...
Homa Kashani, Hojjat Zeraati, Kazem Mohammad, Hamidreza Goodarzynejad, Mahmood Mahmoudi, Saeed Sadeghian, Mohammadali Boroumand   +6 more
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Journal of the Statistical Society.

Mode of access: Internet.Vols. 36-50, 1873-87. 1 v.
Statistical Society (Great Britain)
core  

Clarify: Software for Interpreting and Presenting Statistical Results [PDF]

Clarify is a program that uses Monte Carlo simulation to convert the raw output of statistical procedures into results that are of direct interest to researchers, without changing statistical assumptions or requiring new statistical models.
Gary King, Jason Wittenberg, Micahael Tomz   +2 more
core