Results 81 to 90 of about 27,685,557 (280)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Exact statistical inference for categorical data

, 2016
Exact Statistical Inference for Categorical Data discusses the way asymptotic approaches have been often used in practice to make statistical inference. This book introduces both conditional and unconditional exact approaches for the data in 2 by 2, or 2
Shan, Guogen, Shan, Guogen,author.
core  

Development and preliminary psychometric evaluation of the Psychological Safety Perception scale: An observational study among community pharmacists [PDF]

Vojnosanitetski Pregled
Background/Aim. Measuring psychological safety in the workplace is essential for creating an environment where individuals feel safe expressing themselves, thereby promoting optimal patient care. The aim of the study was to develop a reliable and concise
Jocić Dragana
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Protection of micro-data subject to edit constraints against statistical disclosure

, 2006
Before releasing statistical outputs, data suppliers have to assess if the privacy of the statistical units is endangered and apply Statistical Disclosure Control (SDC) methods if necessary. SDC methods perturb, modify or summarize the data, depending on
Shlomo, Natalie, de Waal, Ton
core  

Report on Statistical Disclosure Limitation Methodology [PDF]

Originally Prepared by Subcommittee on Disclosure Limitation Methodology 1994; Revised by Confidentiality and Data Access Committee 2005The Federal Committee on Statistical Methodology (FCSM) was organized by the Office of Management and Budget (OMB) in ...
United States. Federal Committee on Statistical Methodology
core   +1 more source

INTERPRETATION OF STATISTICAL DATA: THE IMPORTANCE OF AFFECTIVE EXPRESSIONS

STATISTICS EDUCATION RESEARCH JOURNAL, 2017
In recent years, research on teaching and learning of statistics emphasized that the interpretation of data is a complex process that involves cognitive and technical aspects. However, it is a human activity that involves also contextual and affective aspects. This view is in line with research on affectivity and cognition.
Queiroz, Tamires, Monteiro, Carlos, Carvalho, Liliane, Francois, Karen   +3 more
openaire   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Strengthening pharmacy practice: Development and validation of the Resilience Scale [PDF]

Vojnosanitetski Pregled
Background/Aim. Despite the demanding nature of their roles in community pharmacies and their critical importance to patient safety, healthcare professionals, including pharmacists, are often not covered by the Resilience Scale. Therefore, the aim of the
Jocić Dragana
doaj   +1 more source