Results 61 to 70 of about 1,796,099 (244)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Development and preliminary psychometric evaluation of the Psychological Safety Perception scale: An observational study among community pharmacists [PDF]

Vojnosanitetski Pregled
Background/Aim. Measuring psychological safety in the workplace is essential for creating an environment where individuals feel safe expressing themselves, thereby promoting optimal patient care. The aim of the study was to develop a reliable and concise
Jocić Dragana
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Strengthening pharmacy practice: Development and validation of the Resilience Scale [PDF]

Vojnosanitetski Pregled
Background/Aim. Despite the demanding nature of their roles in community pharmacies and their critical importance to patient safety, healthcare professionals, including pharmacists, are often not covered by the Resilience Scale. Therefore, the aim of the
Jocić Dragana
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Statistical Significance versus Clinical Relevance: Key Considerations in Interpretation Medical Research Data

Indian Journal of Community Medicine
Medical research plays a crucial role in advancing our understanding of various aspects related to health, including disease, risk factors, and patient management.
Yousif AbdulRaheem
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Overcoming Missing Data: Accurately Predicting Cardiovascular Risk in Type 2 Diabetes, A Systematic Review

Journal of Diabetes
Understanding is limited regarding strategies for addressing missing value when developing and validating models to predict cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM). This study aimed to investigate the presence of and approaches to
Wenhui Ren, Keyu Fan, Zheng Liu, Yanqiu Wu, Haiyan An, Huixin Liu   +5 more
doaj   +1 more source

Prognostic factors in exacerbated chronic obstructive pulmonary disease

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2021
Background: chronic obstructive pulmonary disease has a high prevalence worldwide. It is important to know the mechanisms that have an influence on the high mortality of the exacerbated form of the disease.Objective: to identify the prognostic factors ...
Iraibis Rodríguez-Pérez, Nelsa María Sagaró-del-Campo, Larisa Zamora-Matamoros, Alejandro Martínez-Álvarez   +3 more
doaj