Results 31 to 40 of about 4,175 (169)
Cancer Medicine, 2018 Background Accurate cancer survival statistics are necessary for describing population‐level survival patterns and measuring advancements in cancer care.
Nupur Makkar +3 more
doaj +1 more source
BMC Medical Research Methodology, 2004 Background We describe a system of web applications designed to streamline the interdisciplinary collaboration in outcomes research. Description The outcomes research process can be described as a set of three interrelated phases: design and selection of
Higgins Laurence D +5 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
The SingHealth Perioperative and Anesthesia Subject Area Registry (PASAR), a large-scale perioperative data mart and registry [PDF]
Korean Journal of AnesthesiologyBackground To enhance perioperative outcomes, a perioperative registry that integrates high-quality real-world data throughout the perioperative period is essential.
Hairil Rizal Abdullah +6 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Data challenges of biomedical researchers in the age of omics [PDF]
PeerJ, 2018 Background High-throughput technologies are rapidly generating large amounts of diverse omics data. Although this offers a great opportunity, it also poses great challenges as data analysis becomes more complex.
Rolando Garcia-Milian +3 more
doaj +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Clarification of Quantitative Intraoral Circumstances with the Community Periodontal Index of Treatment Needs Data using Covariance Structure Analysis [PDF]
Journal of Clinical and Diagnostic Research, 2019 Introduction: Although the severity of periodontal disease is evaluated by various indices, the susceptibility is different among tooth types in the same dentition.
Toshio Kobayashi +7 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source