Results 61 to 70 of about 4,193,923 (352)

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

open access: yesMolecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen   +13 more
wiley   +1 more source

Interpretability of machine-learning models in physical sciences [PDF]

open access: yesarXiv, 2021
In machine learning (ML), it is in general challenging to provide a detailed explanation on how a trained model arrives at its prediction. Thus, usually we are left with a black-box, which from a scientific standpoint is not satisfactory. Even though numerous methods have been recently proposed to interpret ML models, somewhat surprisingly ...
arxiv  

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini   +11 more
wiley   +1 more source

Sexual dimorphism of the human corpus callosum: Digital morphometric study [PDF]

open access: yesVojnosanitetski Pregled, 2006
Background/Aim. Changes in the morphology and the size of the corpus callosum, are related to various pathological conditions. An analysis of these changes requires data about sexual dimorphism of the corpus callosum, which we tried to obtain in our ...
Spasojević Goran   +3 more
doaj   +1 more source

Survival Analysis and Interpretation of Time-to-Event Data: The Tortoise and the Hare

open access: yesAnesthesia and Analgesia, 2018
Survival analysis, or more generally, time-to-event analysis, refers to a set of methods for analyzing the length of time until the occurrence of a well-defined end point of interest.
P. Schober, T. Vetter
semanticscholar   +1 more source

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

open access: yesMolecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke   +12 more
wiley   +1 more source

Understanding sensitivity, specificity and predictive values [PDF]

open access: yesVojnosanitetski Pregled, 2014
nema
Stojanović Miodrag   +6 more
doaj   +1 more source

Statistical approach to interpretation of geochemical data of stream sediment in Pleše mining area

open access: yesGeologija, 2022
The Ba, Pb and Zn ore deposit Pleše near Ljubljana is one of the formerly productive mines. The stream sediments were sampled and analysed by XRF to establish the effect of grain size, mineralization, and downstream location of sampling sites on ...
Simona Jarc
doaj   +1 more source

Basic statistical tools in research and data analysis

open access: yesIndian Journal of Anaesthesia, 2016
Statistical methods involved in carrying out a study include planning, designing, collecting data, analysing, drawing meaningful interpretation and reporting of the research findings.
Zulfiqar Ali, S. Bhaskar
semanticscholar   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

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