Results 61 to 70 of about 339,713 (264)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A New Generalization of the Lomax Distribution with Increasing, Decreasing, and Constant Failure Rate

Modelling and Simulation in Engineering, 2017
Developing new compound distributions which are more flexible than the existing distributions have become the new trend in distribution theory. In this present study, the Lomax distribution was extended using the Gompertz family of distribution, its ...
Pelumi E. Oguntunde, Mundher A. Khaleel, Mohammed T. Ahmed, Adebowale O. Adejumo, Oluwole A. Odetunmibi   +4 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

General Distribution Theory of the Concomitants of Order Statistics

The Annals of Statistics, 1977
Let $(X_i, Y_i) (i = 1, 2, \cdots, n)$ be $n$ independent $\mathrm{rv}$'s from some bivariate distribution. If $X_{r:n}$ denotes the $r$th ordered $X$-variate, then the $Y$-variate $Y_{\lbrack r:n\rbrack}$ paired with $X_{r:n}$ is termed the concomitant of the $r$th order statistics.
openaire   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

On Approaching Normality Through Rectangular Distribution: Industrial Applications to Monitor Electron Gun and File Server Processes

Journal of Statistical Theory and Applications (JSTA)
Normal probability distribution is central to most statistical methods and their applications. In many real scenarios, the normality of the underlying phenomenon is not obvious.
Muhammad Riaz, Anwar H. Joarder, M. Hafidz Omar, Tahir Mahmood, Nasir Abbas   +4 more
doaj   +1 more source

New Advances in Distribution Theory and Its Applications

Mathematics
In recent years, the prolific development of new statistical distributions via various techniques has often led to increased complexity without necessarily enhancing model flexibility or parameter interpretability, a trend that has sometimes diminished ...
Filippo Domma, Francesca Condino
doaj   +1 more source

Statistical Investigation of Bearing Capacity of Pile Foundation Based on Bayesian Reliability Theory

Advances in Civil Engineering, 2019
In order to improve the estimation accuracy of bearing capacity of pile foundation, a new forecast method of bearing capacity of pile foundation was proposed on Jeffrey’s noninformative prior using the MCMC (Markov chain Monte Carlo) method of the ...
Zuolong Luo, Fenghui Dong
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source