CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
rtpcr: a package for statistical analysis and graphical presentation of qPCR data in R. [PDF]
Mirzaghaderi G.
europepmc +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Inconsistency was more prevalent than reported: an empirical study of 57 networks with multiple treatments using the node-splitting approach and a novel interpretation index. [PDF]
Spineli LM.
europepmc +1 more source
Exploratory Factor Analysis: A Five-Step Guide for Novices
B. Williams, A. Onsman, T. Brown
semanticscholar +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
MAFF inhibits angiogenesis in non-small cell lung cancer by suppressing YAP1 nuclear translocation. [PDF]
Ding Y +10 more
europepmc +1 more source
Translation, Adaptation, and Validation of Hindi Version of the Pain Catastrophizing Scale: Statistical Issues of Confirmatory Factor Analysis to Avoid Misinterpretation [PDF]
Erfan Ayubi +2 more
openalex +1 more source

