Results 241 to 250 of about 8,264,393 (332)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Translation and Validation of the Arabic Version of the Revised Restrictive Behaviours Scale Among Iraqi Children With Autism Spectrum Disorder: A Suggestion for Model Modification. [PDF]

Int J Methods Psychiatr Res
Hussein Al-Sultan RR, Jasim SM, Lami F, Jaber OA, Nayeri ND, Sabet MS, Al-Gburi G.   +6 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Correction: REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis. [PDF]

J Exp Med
Hu X, Liu Z, Li Y, You Y, Yue K, Liang Y, Loo CS, Yu J, Leblanc M, Wang D, Li H, Zheng Y.   +11 more
europepmc   +1 more source

Análisis de sistema de potencia desbalanceado con el empleo de herramientas estadísticas, coeficientes complejos y redes neuronales artificiales; Statistical, Complex Factor and Neural Networks Analysis and Simulation of an Unbalance Power Systems

, 2011
Marcos Alberto de Armas Teyra, Julio R. Gómez Sarduy, Percy Rafael Viego Felipe, Carlos Pérez Tello   +3 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Bile metabolite palmitic acid augments the migration of gallbladder cancer cells through the ROS/NF-кB signaling pathway. [PDF]

Sci Rep
Da X, Guo Q, Lu Y, Huang J, Mo J, Lu L, Fan M, Zhao X, Guo T, Qi Z, Haoshang, Lu H.   +11 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The role and potential mechanism of PEST-containing nuclear protein (PCNP) in endothelial cell angiogenesis in vitro. [PDF]

Sci Rep
Du Y, Xu C, Dang Y.
europepmc   +1 more source

Statistical Analysis of ROOFER Database from 21 Army Installations: Assessment of Army Membrane Roofing Inventory and Effects of Various Factors on Roof Condition.

, 1997
David M. Bailey, Douglas G. Simpson, Xuming He, Olga Geling, Shun Lau   +4 more
openalex   +1 more source