Results 101 to 110 of about 398,172 (288)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Escaping RGBland: Selecting colors for statistical graphics
Computational Statistics & Data Analysis, 2009 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Zeileis, Achim +2 more
openaire +4 more sources
Correspondence analysis of the Spanish National Health Survey
Gaceta Sanitaria, 2002 This report gives a comprehensive explanation of the multivariate technique called correspondence analysis, applied in the context of a large survey of a nation's state of health, in this case the Spanish National Health Survey.
Greenacre M.
doaj
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
State of the Art in Parallel Computing with R [PDF]
R is a mature open-source programming language for statistical computing and graphics. Many areas of statistical research are experiencing rapid growth in the size of data sets. Methodological advances drive increased use of simulations.
Dirk Eddelbuettel +5 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Prognostic Significance of Perineural Invasion in Patients with Rectal Cancer using R Environment for Statistical Computing and Graphics [PDF]
Applied Medical Informatics, 2012 Purpose: In recent studies perineural invasion (PNI) is associated with poor survival rates in rectal cancer, but the impact of PNI it’s still controversial. We assessed PNI as a potential prognostic factor in rectal cancer.
Ioan Catalin VLAD +3 more
doaj
Analysing circular data in Stata [PDF]
Circular data are a large class of directional data, which are of interest to scientists in many fields, including biologists (movements of migrating animals), meteorologists (winds), geologists (directions of joints and faults) and geomorphologists ...
Nicholas J. Cox
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source