Results 81 to 90 of about 398,172 (288)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Vista: A Software for Teaching Statistics and Psychometrics
Revista Argentina de Ciencias del Comportamiento, 2010 Nowadays, teaching statistics is almost undisputedly always done using some sort of software for carrying out the computations. Indeed, the range of choices available for that purpose is wide and with a lot of variety.
Valero-Mora, Pedro +2 more
doaj
Góndola, Enseñanza y Aprendizaje de las Ciencias, 2015 Se busca recuperar los resultados de una investigación llevada a cabo dentro la asignatura Práctica intermedia III, correspondiente al sexto semestre del proyecto curricular Licenciatura en Educación Básica con Énfasis en Matemáticas LEBEM, de la ...
Angélica Marcela Ruiz Molano
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Using R to Teach Econometrics. [PDF]
R, an open-source programming environment for data analysis and graphics, has in only a decade grown to become a de-facto standard for statistical analysis against which many popular commercial programs may be measured.
Hyndman, R.J., Racine, J
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
3D Heritage Artefacts in Education—Enhancing Attractiveness of Computer Graphics Curriculum
Applied SciencesLublin University of Technology has been offering computer science studies for over 25 years. From the beginning, computer graphics have played a crucial role in the studies program.
Kamil Żyła +2 more
doaj +1 more source
Computational tools for multi-linked flexible structures [PDF]
A software module which designs and tests controllers and filters in Kalman Estimator form, based on a polynomial state-space model is discussed. The user-friendly program employs an interactive graphics approach to simplify the design process. A variety
Brubaker, Thomas A. +2 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source