In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock +8 more
wiley +1 more source
Investigating memory episodes in location probability learning: Can altering response features reset spatial bias? [PDF]
Atten Percept PsychophysYu X, Woodman GF.
europepmc +1 more source
Association of the ICH Score With Withdrawal of Life‐Sustaining Treatment Over a 10‐Year Period
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The intracerebral hemorrhage (ICH) score was developed to enhance provider communication and facilitate early severity assessment. We examined the association of the ICH score with mortality and withdrawal of life‐sustaining treatment (WLST) in a large, multicenter stroke registry, and evaluated temporal trends in these associations.
Nina Massad +15 more
wiley +1 more source
Digital Activity Markers in Chronic Inflammatory Demyelinating Polyneuropathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the utility of smartwatch and smartphone‐based activity metrics for assessing disease severity and quality of life in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Methods In the electronic monitoring of disease activity in patients with CIDP (EMDA‐CIDP) trial, we performed a prospective ...
Lars Masanneck +15 more
wiley +1 more source
Cats and external cervical resorption: Statistical considerations. [PDF]
Int Endod JBashir NZ, Bernabé E.
europepmc +1 more source
The Road Not Taken: Misclassifying an Anti‐Seizure Medication as a Failure
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To quantify how often anti‐seizure medications (ASMs) appear ineffective yet provide benefit when considering seizure frequency (SF) variability. Methods We used the CHOCOLATES seizure diary simulator to generate 100,000 patient seizure diaries that reflect natural SF variation in a heterogeneous population.
Christopher N. Henry +1 more
wiley +1 more source
Testing for a General Changepoint in Medical and Psychometric Studies: Changes Detection and Sample Size Planning. [PDF]
Stat MedD'Angelo N.
europepmc +1 more source
Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including Parkinson's disease and Dementia with Lewy bodies.
S. Koay +12 more
wiley +1 more source
Scalable geometric learning with correlation-based functional brain networks. [PDF]
Sci RepYou K, Lee Y, Park HJ.
europepmc +1 more source
StatWhy: Formal Verification Tool for Statistical Hypothesis Testing Programs [PDF]
Yusuke Kawamoto +2 more
openalex +1 more source