Results 41 to 50 of about 823,510 (266)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The extension of the largest generalized-eigenvalue based distance metric ) in arbitrary feature spaces to classify composite data points [PDF]

Genomics & Informatics, 2019
Analyzing patterns in data points embedded in linear and non-linear feature spaces is considered as one of the common research problems among different research areas, for example: data mining, machine learning, pattern recognition, and multivariate ...
Mosaab Daoud
doaj   +1 more source

Automatic Detection of Cognitive Impairment with Virtual Reality

Sensors, 2023
Cognitive impairment features in neuropsychiatric conditions and when undiagnosed can have a severe impact on the affected individual’s safety and ability to perform daily tasks.
Farzana A. Mannan, Lilla A. Porffy, Dan W. Joyce, Sukhwinder S. Shergill, Oya Celiktutan   +4 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Stacking Ensemble Learning for Genomic Prediction Under Complex Genetic Architectures

Agronomy
Genomic selection (GS) estimates the GEBV from genome-wide markers to reduce generation intervals and optimize germplasm selection, which is particularly advantageous for high-cost or late-expressed traits.
Maurício de Oliveira Celeri, Moyses Nascimento, Ana Carolina Campana Nascimento, Filipe Ribeiro Formiga Teixeira, Camila Ferreira Azevedo, Cosme Damião Cruz, Laís Mayara Azevedo Barroso   +6 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A General Formulation of the Kinematic Dipole as a Functional of Selection and Source Properties: Beyond the Ellis–Baldwin Approximation

The Astrophysical Journal Supplement Series
The dipole anisotropy in galaxy and QSO number counts induced by the observer’s motion, known as the kinematic dipole, provides an important test of cosmological isotropy and an independent comparison with the dipole of the cosmic microwave background ...
Tsutomu T. Takeuchi
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Assessment of bowel cleansing quality in colon capsule endoscopy using machine learning: a pilot study

Endoscopy International Open, 2018
Background and study aims The aim of this study was to develop a machine learning-based model to classify bowel cleansing quality and to test this model in comparison to a pixel analysis model and assessments by four colon capsule endoscopy (CCE) readers.
Maria Magdalena Buijs, Mohammed Hossain Ramezani, Jürgen Herp, Rasmus Kroijer, Morten Kobaek-Larsen, Gunnar Baatrup, Esmaeil S. Nadimi   +6 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source