Results 101 to 110 of about 468,748 (305)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Partial identification in statistical matching with misclassification
International Journal of Approximate Reasoning, 2017 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Di Zio, Marco, VANTAGGI, Barbara
openaire +2 more sources
Is there a Superior Distance Function for Matching in Small Samples? [PDF]
The study contributes to the development of ’standards’ for the application of matching algorithms in empirical evaluation studies. The focus is on the first step of the matching procedure, the choice of an appropriate distance function.
Claudia Becker +2 more
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Journal of Statistics Education, 2019 The purpose of this study was to study the impact of conformity to statistical reasoning learning environment (SRLE) principles on students’ statistical reasoning in advanced placement statistics courses.
Basil Conway +4 more
doaj +1 more source
On the implementation of local probability matching priors for interest parameters [PDF]
, 2005 Probability matching priors are priors for which the posterior probabilities of certain specified sets are exactly or approximately equal to their coverage probabilities.
Sweeting, TJ, Trevor J. Sweeting
core +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
A NOVEL POST-HOC MATCHING PROCEDURE USING STATISTICAL LEARNING METHODS [PDF]
, 2016 In this thesis, a statistical learning method is leveraged to create a novel measure for conducting post-hoc matching between a treatment group and a candidate set.
Perret, Olivia
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source