Results 91 to 100 of about 468,748 (305)

Statistical matching by Bayesian Networks

, 2018
The goal of statistical matching is the estimation of the joint distribution of variables not jointly observed in a sample survey but separately available from independent sample surveys.
paola vicard, daniela marella, vincenzina vitale   +2 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Dynamic SLAM algorithm adopt with eliminating mismatched point chains in grid motion statistics

Scientific Reports
Feature matching is an essential part in areas such as target tracking, and three-dimensional reconstruction. In case of rotational motion in the image, the rotating exercise core 8 statistical motion support volume is applied, resulting in low matching ...
Yong He, Jiangtao Yu, Xiaochuan He
doaj   +1 more source

How much reliable are the integrated 'live' data? A validation strategy proposal for the non-parametric micro statistical matching. [PDF]

J Appl Stat, 2021
D'Alberto R, Raggi M.
europepmc   +1 more source

UK Alcohol Treatment trial: client-treatment matching effects

, 2008
Aim To test a priori hypotheses concerning client–treatment matching in the treatment of alcohol problems and to evaluate the more general hypothesis that client–treatment matching adds to the overall effectiveness of treatment. Design Pragmatic,
Raistrick, Duncan, Copello, Alex, McBride, Andrew, Carlyle, Kate, UKATT Res Team, Parkes, Sue, Morton, Veronica, Barrett, Clive, Tober, Gillian, John, Bev, Kenyon, Rob, Kerr, Cicely, Godfrey, Christine, Slegg, Gary P., Smith, Melanie, Chalk, Pauline, UKATT Research Team, Alwyn, Tina, Fleming, Annette, Russell, Ian, Orford, Jim, Hodgson, Ray, Emlyn-Jones, Rhoda, Williams, Paul, Crome, Illana, Kahn, Ash, Farrin, Amanda, Gillam, Racheal, Handforth, Linda, Heather, Nick, Black, Rachel, Coulton, Simon, Parrott, Steve, Champney-Smith, Jeff, Summers, Zelda   +34 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Incoherence correction strategies in statistical matching

International Journal of Approximate Reasoning, 2012
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Alessandro Brozzi, Andrea Capotorti, Barbara Vantaggi   +2 more
openaire   +2 more sources

Uncertainty in statistical matching for complex sample surveys

, 2014
An important feature of statistical matching is the estimation of the underlying joint distribution of variables separately available from independent sample surveys.
CONTI, Pier Luigi, Scanu, Mauro, Marella, Daniela   +2 more
core