Results 31 to 40 of about 16,729 (258)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A Statistical Mechanical View of the Determination of the Composition of Multi?Temperature Plasmas [PDF]

Plasma Chemistry and Plasma Processing, 2004
It is important that plasma composition is calculated in a manner consistent with statistical mechanics, particularly since the Boltzmann equation is the basis from which transport coefficients and the fluid‐dynamic equations are derived. It is shown from statistical mechanical considerations based on the Boltzmann equation and the H‐theorem that it is
André, Pascal, Aubreton, Jacques, Elchinger, Marie-Françoise, Rat, Vincent, Fauchais, Pierre, Lefort, A., Murphy, A.B   +6 more
openaire   +3 more sources

Uniform derivation of Coulomb collisional transport thanks to Debye shielding [PDF]

, 2014
The effective potential acting on particles in plasmas being essentially the Debye-shielded Coulomb potential, the particles collisional transport in thermal equilibrium is calculated for all impact parameters $b$, with a convergent expression reducing ...
Doveil, Fabrice, Elskens, Yves, Escande, Dominique F.   +2 more
core   +3 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

STATISTICAL MECHANICS OF DENSE PLASMAS : ASTROPHYSICAL APPLICATIONS

Le Journal de Physique Colloques, 1978
Low mass main sequence stellar interiors are strongly coupled moderately dense plasma mixtures that are well described by Monte Carlo simulations with electron screening included. Other applications include the very high density interiors of white dwarf stars, possible comparison with experimental measurements in laser-fusion pellet compression ...
openaire   +2 more sources

The nonextensive parameter for the rotating astrophysical systems with power-law distributions

, 2016
We study the nonextensive parameter for the rotating astrophysical systems with power-law distributions, including both the rotating self-gravitating system and the rotating space plasma. We extend the equation of nonextensive parameter to complex system
Du, Jiulin, Yu, Haining
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Vlasov equation and $N$-body dynamics - How central is particle dynamics to our understanding of plasmas?

, 2014
Difficulties in founding microscopically the Vlasov equation for Coulomb-interacting particles are recalled for both the statistical approach (BBGKY hierarchy and Liouville equation on phase space) and the dynamical approach (single empirical measure on ...
Doveil, Fabrice, Elskens, Yves, Escande, D. F.   +2 more
core   +3 more sources

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source