Results 91 to 100 of about 5,876,781 (310)
Why Write Statistical Software? The Case of Robust Statistical Methods
, 2004 Robust statistical methods are designed to work well when classical assumptions, typically normality and/or the lack of outliers, are violated. Almost everyone agrees on the value of robust statistical procedures.
Arnold J. Stromberg +2 more
core +1 more source
Statistical Scale Space Methods [PDF]
, 2017 SummaryThe goal of statistical scale space analysis is to extract scale-dependent features from noisy data. The data could be for example an observed time series or digital image in which case features in either different temporal or spatial scales would
Ruha (née Pasanen), Leena +1 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Biology Direct, 2018 Background The experience with running various types of classification on the CAMDA neuroblastoma dataset have led us to the conclusion that the results are not always obvious and may differ depending on type of analysis and selection of genes used for ...
Anna Leśniewska +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2020 Forecasting the U.S. employment level is made using machine learning methods of the artificial neural network: deep neural network, long short term memory (LSTM), gated recurrent unit (GRU).
신동완
core +1 more source
Refining bootstrap methods in dependent data structures : is there room for improvement? [PDF]
, 2010 According to Efron and Tibshirani (1993), the traditional road to statistical knowledge is blocked, for most, by a formidable wall of mathematics. The usefulness of the bootstrap method is particularly appreciable when dealing with complex estimators or ...
G. Manzi
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source