Results 191 to 200 of about 34,159,249 (310)

Artificial intelligence-based statistical modeling delineates architectural distortion in focal cortical dysplasia. [PDF]

Brain Pathol
Cannon A, Tian R, Ebner B, Watson RE, Burkett B, Van Gompel J, Wong-Kisiel LC, Hartley CP, Moreira RK, Raghunathan A.   +9 more
europepmc   +1 more source

Statistical Digital Signal Processing and Modeling

, 1996
Marvin H. J. Gruber, Monson H. Hayes
semanticscholar   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Metabolic Risk Predictors Associated With the Onset of Vascular Complications Among Patients With Type 2 Diabetes in Zambia: A Retrospective Statistical Modeling Study. [PDF]

Health Sci Rep
Mwalungali G, Chilengwe W, Mwaba J, Kazonga E, Mutemwa R, Kampamba M, Mweetwa L, Hamachila A, Mutati C, Munsaka S, Hangomma J, Milomba R, Malambo M, Chisunka C, Mzaza N, Buumba P, Bwalya C, Mwansa P.   +17 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Optimization of HPAM Polymer Flooding for Enhanced Oil Recovery Through Experimental Core Flooding and Predictive Statistical Modeling. [PDF]

Polymers (Basel)
Khormali A, Ahmadi S.
europepmc   +1 more source

Statistical modeling of nitrogen-dependent modulation of root system architecture in Arabidopsis thaliana.

Journal of Integrative Plant Biology, 2016
Takao Araya, Takuya Kubo, N. von Wirén, Hideki Takahashi   +3 more
semanticscholar   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Systematic evaluation and statistical modeling of dual centrifugation and high-pressure homogenization as promising methods for scalable preparation of polymeric nanoparticles. [PDF]

Discov Nano
Kamel AE, Klein S, Schöne L, Gabr S, Bakowsky U, Schäfer J.   +5 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source