Results 171 to 180 of about 34,159,249 (310)

An Exploratory Statistical Modeling Framework for National Rule-of-Law Profiles. [PDF]

Entropy (Basel)
Çelik S, Köroğlu MA, Köroğlu CZ.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

An approximate-copula distribution for statistical modeling. [PDF]

PLoS Comput Biol
Ji SS, Chu BB, Zhou H, Lange K.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Statistical modeling of days alive out-of-hospital: An illustration using the SSU trial. [PDF]

J Clin Transl Sci
Wu X, Berger DA, Bischof JJ, Char D, Diercks D, Hess EP, Jones AE, Lane KA, Levy P, Li X, Miller JB, Mahler SA, Pressler SJ, Venkat A, Pang PS, Collins S, Blette BS.   +16 more
europepmc   +1 more source

Statistical Policy Working Paper 16. A Comparative Study of Reporting Units in Selected Employer Data Systems

The Employer Reporting Unit Match Study (ERUMS) was a pilot record linkage study carried out under the auspices of the Federal Committee on Statistical Methodology (FCSM), Office of Management and Budget.
United States. Federal Committee on Statistical Methodology
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Lasercom Uncertainty Modeling and Optimization Simulation (LUMOS): a Statistical Approach to Risk-tolerant Systems Engineering for Small Satellites

, 2019
In contrast to large-budget space missions, risk-tolerant platforms such as nanosatellites may be better positioned to exchange moderate performance uncertainty for reduced cost and improved manufacturability.
Cahoy, Kerri, Clements, Emily B, Caplan, David O., Mendenhall, Jeffrey A.   +3 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Comparative Evaluation of Machine Learning-Assisted Statistical Modeling of Biopolymer Hydrogel Swelling for Material Optimization. [PDF]

ACS Omega
Sharma Y, Roy SD, Das R, Manian R, Gurusamy A, Shankar V.   +5 more
europepmc   +1 more source