Results 161 to 170 of about 2,324,497 (297)

Methodological Considerations Regarding Heterogeneity and Statistical Modeling in "Effects on Exercise Tolerance and Functional Outcomes of Eccentric versus Concentric Aerobic Exercise in People with COPD" [Letter]. [PDF]

Int J Chron Obstruct Pulmon Dis
Otto-Yáñez M, Torres-Castro R, Vilaró J.   +2 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Stable isotope and multi-elemental analysis combined with statistical modeling for saffron origin authentication. [PDF]

Food Chem X
Terro C, Strojnik L, Potočnik D, Hudobivnik MJ, Mazej D, Bontempo L, Eddabdouby M, Amenzou NE, Moncef B, Kelly S, Ogrinc N.   +10 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Strategic utilization of chicken bones immobilized by Aspergillus terreus for sustainable bioremediation of cobalt: statistical modeling, kinetics and thermodynamic studies. [PDF]

J Biol Eng
Eltarahony M, El-Gamal EH, Salama MM, Ibrahim A.   +3 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Prolonged growth and extended subadult development in the <i>Tyrannosaurus rex</i> species complex revealed by expanded histological sampling and statistical modeling. [PDF]

PeerJ
Woodward HN, Myhrvold NP, Horner JR.
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Statistical modeling the seroprevalence of hepatitis B among the pregnant women attending specialist hospital, Idah, kogi state, Nigeria. [PDF]

BMC Infect Dis
Aye G, Olatayo Olusegun A.
europepmc   +1 more source

spmodel: Spatial statistical modeling and prediction in R. [PDF]

PLoS One, 2023
Dumelle M, Higham M, Ver Hoef JM.
europepmc   +1 more source