Results 151 to 160 of about 775,359 (318)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Modeling population uncertainty using statistical moments [PDF]
, 2012 [EN] In this paper a random differential equation system modeling population dynamics is investigated by means of the statistical moments equation. Monte Carlo simulations are performed in order to compare with the statistical moments equation approach ...
Villanueva Micó, Rafael Jacinto +3 more
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
The future of pandemic modeling in support of decision making: lessons learned from COVID-19
BMC Global and Public HealthThe devastating global impacts of the COVID-19 pandemic are a stark reminder of the need for proactive and effective pandemic response. Disease modeling and forecasting are key in this response, as they enable forward-looking assessment and strategic ...
Kelly R. Moran +2 more
doaj +1 more source
Comments about the use of PLS path modeling in building a Job Quality Composite Indicator [PDF]
, 2015 A composite indicator is formed when elementary indicators are compiled into a single index, on the basis of an underlying model of the mul- tidimensional concept that is being measured. The PLS path modeling allows the estimation of composite indicators
Padua, Department of Statistical Sciences University of +3 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
A Hierarchical Statistical Engineering Modeling Methodology [PDF]
, 2016 In the ASEM-IAC 2015, Cotter (2015) proposed a systemic joint deterministic-stochastic dynamic causal Bayesian statistical engineering model that addressed the knowledge gap needed to integrate deterministic mathematical engineering models within a ...
Cotter, Teddy Steven
core +1 more source