Results 91 to 100 of about 4,524,322 (288)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Journal of Statistical Physics
The Journal of Statistical Physics publishes original papers in all areas of statistical physics as well as in related fields concerned with collective phenomena in physical ...
Marco Lenci
core +1 more source
Statistical Complexity of the Coriolis Antipairing Effect
, 2019 Using the entropic quantifier called statistical complexity, we investigate the interplay between (1) pairing interactions between fermions, can be viewed as analogous with superconductivity based on Cooper pairs; (2) rotations of the system as a whole ...
Flavia Pennini, Angelo Plastino
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Collective dynamics of swarmalators with higher-order interactions
Communications PhysicsHigher-order interactions shape collective dynamics, but how they affect transitions between different states in swarmalator systems is yet to be determined. To that effect, we here study an analytically tractable swarmalator model that incorporates both
Md Sayeed Anwar +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Gravitational wave propagation in a geometric condensate in Starobinsky cosmology
European Physical Journal C: Particles and FieldsIn this paper we propose a new paradigm for cosmology: a time dependent scalar condensate background originated from the quadratic $$(R + \alpha R^2)$$ ( R + α R 2 ) Starobinsky model, where R is the Ricci scalar and $$\alpha $$ α the coupling constant ...
Aurindam Mondal, Subir Ghosh
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Thermodynamic efficiency in dissipative chemistry
Nature Communications, 2019 Open chemical systems operate out of equilibrium, providing more opportunities than closed systems, but a theoretical framework to describe their performance is lacking. Here, the authors assess the efficiency of two classes of dissipative processes with
Emanuele Penocchio +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source