Results 101 to 110 of about 232,992 (299)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Justifying Typicality Measures of Boltzmannian Statistical Mechanics and Dynamical Systems [PDF]

, 2013
A popular view in contemporary Boltzmannian statistical mechanics is to interpret the measures as typicality measures. In dynamical systems theory measures can similarly be interpreted as typicality measures.
Werndl, Charlotte
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Statistical thermodynamics of charge-stabilized colloids

, 2008
This thesis is a theoretical study of equilibrium statistical thermodynamic properties of colloidal systems in which electrostatic interactions play a dominant role, namely, charge-stabilized colloidal suspensions. Such systems are fluids consisting of a
Torres Valderrama, A., Dep Natuurkunde, Condensed Matter Theory, Statistical and Computational Physics   +2 more
core  

Theoretical physics 8: statistical physics

, 2018
This textbook offers a clear and comprehensive introduction to statistical physics, one of the core components of advanced undergraduate physics courses.
Nolting, Wolfgang, Wolfgang Nolting
core   +1 more source

Simulating the Photochemical Birth of the Hydrated Electron in Liquid Water

Nature Communications
The photochemistry of UV-irradiated liquid water underlies many physical, chemical, and biological processes, with the formation of the hydrated electron as a central event.
Gonzalo Díaz Mirón, Cesare Malosso, Solana Di Pino, Colin K. Egan, Diganta Dasgupta, Christopher J. Mundy, Ali Hassanali   +6 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Statistical physics

, 2012
This volume provides a compact presentation of modern statistical physics at an advanced level. Beginning with questions on the foundations of statistical mechanics all important aspects of statistical physics are included, such as applications to ideal ...
Sadovskii, Michael V
core  

Primordial gravitational waves as probe of dark matter in interferometer missions: Fisher forecast and MCMC

Journal of High Energy Physics
We propose novel inflationary primordial gravitational wave (GW) spectral shapes at interferometer-based current and future GW missions to test dark matter (DM) production via gravity-portal.
Anish Ghoshal, Debarun Paul, Supratik Pal   +2 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source