Results 101 to 110 of about 6,862,090 (312)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Randomly Spread CDMA: Asymptotics via Statistical Physics

open access: yes, 2005
This paper studies randomly spread code-division multiple access (CDMA) and multiuser detection in the large-system limit using the replica method developed in statistical physics. Arbitrary input distributions and flat fading are considered.
Guo, Dongning, Verdu, Sergio
core   +3 more sources

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Collective dynamics of swarmalators with higher-order interactions

open access: yesCommunications Physics
Higher-order interactions shape collective dynamics, but how they affect transitions between different states in swarmalator systems is yet to be determined. To that effect, we here study an analytically tractable swarmalator model that incorporates both
Md Sayeed Anwar   +3 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Gravitational wave propagation in a geometric condensate in Starobinsky cosmology

open access: yesEuropean Physical Journal C: Particles and Fields
In this paper we propose a new paradigm for cosmology: a time dependent scalar condensate background originated from the quadratic $$(R + \alpha R^2)$$ ( R + α R 2 ) Starobinsky model, where R is the Ricci scalar and $$\alpha $$ α the coupling constant ...
Aurindam Mondal, Subir Ghosh
doaj   +1 more source

Stars and statistical physics: a teaching experience

open access: yes, 1999
The physics of stars, their workings and their evolution, is a goldmine of problems in statistical mechanics and thermodynamics. We discuss many examples that illustrate the possibility of deepening student's knowledge of statistical mechanics by an ...
Balian, R., Blaizot, J. -P.
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Thermodynamic efficiency in dissipative chemistry

open access: yesNature Communications, 2019
Open chemical systems operate out of equilibrium, providing more opportunities than closed systems, but a theoretical framework to describe their performance is lacking. Here, the authors assess the efficiency of two classes of dissipative processes with
Emanuele Penocchio   +2 more
doaj   +1 more source

Statistical physics of liquid brains

open access: yesbioRxiv, 2018
Liquid neural networks (or “liquid brains”) are a widespread class of cognitive living networks characterised by a common feature: the agents (ants or immune cells, for example) move in space.
Jordi Piñero, R. Solé
semanticscholar   +1 more source

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