Results 71 to 80 of about 5,016,192 (334)

A Physicist’s View on Partial 3D Shape Matching

open access: yesAlgorithms, 2023
A new algorithm is presented to compute nonrigid, possibly partial comparisons of shapes defined by unstructured triangulations of their surfaces.
Patrice Koehl, Henri Orland
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

Cascading failures in anisotropic interdependent networks of spatial modular structures

open access: yesNew Journal of Physics, 2021
The structure of real-world multilayer infrastructure systems usually exhibits anisotropy due to constraints of the embedding space. For example, geographical features like mountains, rivers and shores influence the architecture of critical ...
Dana Vaknin   +4 more
doaj   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

open access: yesMolecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza   +3 more
wiley   +1 more source

Statistical physics of crime: A review [PDF]

open access: yesPhysics of Life Reviews, 2015
15 two-column pages, 11 figures; accepted for publication in Physics of Life ...
Matjaz Perc   +3 more
openaire   +5 more sources

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Seismicity, Statistical Physics Approaches to [PDF]

open access: yes, 2009
revised version accepted for the Encyclopedia of Complexity and Systems Science ...
Sornette, Didier, Werner, Maximilian J
openaire   +4 more sources

Tropical limit in statistical physics [PDF]

open access: yesPhysics Letters A, 2015
Tropical limit for macroscopic systems in equilibrium defined as the formal limit of Boltzmann constant k going to 0 is discussed. It is shown that such tropical limit is well-adapted to analyse properties of systems with highly degenerated energy levels, particularly of frustrated systems like spin ice and spin glasses.
Angelelli,M, KONOPELCHENKO, Boris
openaire   +3 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

open access: yesFEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik   +2 more
wiley   +1 more source

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