Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang +16 more
wiley +1 more source
Design and analysis of factorial clinical trials: The impact of one treatment's effectiveness on the statistical power and required sample size of the other. [PDF]
Stat Methods Med Res, 2023 Walter SD, Belo IJ.
europepmc +1 more source
How much power is enough? Against the development of an arbitrary convention for statistical power calculations [PDF]
, 2003 Julian Di Stefano
openalex +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objectives An increasing body of evidence indicates altered DNA methylation in Parkinson's disease, yet the reproducibility and utility of such methylation changes are largely unexplored. We aimed to further elucidate the role of dysregulated DNA methylation in Parkinson's disease and to evaluate the biomarker potential of methylation‐based ...
Ingeborg Haugesag Lie +4 more
wiley +1 more source
The paired t-test as a simple latent change score model
Frontiers in Psychology, 2013 Emil N Coman +5 more
doaj +1 more source
Statistical power in clinical trials of interventions for mood, anxiety, and psychotic disorders. [PDF]
Psychol Med, 2023 de Vries YA +4 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objectives This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). Methods A prospective case–control study comparing proteomic, metabolomic, and immune profiles in individuals with DSRD was performed.
Jonathan D. Santoro +12 more
wiley +1 more source
Automatic CTF correction for single particles based upon multivariate statistical analysis of individual power spectra [PDF]
, 2003 Bjoern Sander +2 more
openalex +1 more source
Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective Idiopathic intracranial hypertension (IIH) is a neurological disorder predominantly affecting young women with obesity, characterized by elevated intracranial pressure. While current treatments include weight loss counseling, medical therapies, and surgical interventions, their limitations necessitate exploring novel therapeutic ...
Ahmed Y. Azzam +13 more
wiley +1 more source
Statistical power: Implications for planning MEG studies. [PDF]
Neuroimage, 2021 Chaumon M, Puce A, George N.
europepmc +1 more source