Results 41 to 50 of about 1,502,987 (305)

Estimating statistical power for detecting long term trends in surface water Escherichia coli concentrations

open access: yesTexas Water Journal, 2021
Water quality monitoring programs commonly use the Mann-Kendall test or linear regression to identify statistically significant monotonic trends in fecal indicator bacteria concentrations (typically Escherichia coli [E. coli]).
Michael Paul Schramm
doaj  

Statistical power for detecting epistasis QTL effects under the F-2 design

open access: yesGenetics Selection Evolution, 2005
Epistasis refers to gene interaction effect involving two or more genes. Statistical methods for mapping quantitative trait loci (QTL) with epistasis effects have become available recently.
Da Yang, Mao Yongcai
doaj   +1 more source

Published correlational effect sizes in social and developmental psychology

open access: yesRoyal Society Open Science, 2022
The distribution of effect sizes may offer insights about the research done and reported in a scientific field. We have evaluated 12 412 manually collected correlation effect sizes (Sample 1) and 31 157 computer-extracted correlation effect sizes (Sample
Josefína Weinerová   +2 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

The Vacc-SeqQC project: Benchmarking RNA-Seq for clinical vaccine studies

open access: yesFrontiers in Immunology, 2023
IntroductionOver the last decade, the field of systems vaccinology has emerged, in which high throughput transcriptomics and other omics assays are used to probe changes of the innate and adaptive immune system in response to vaccination.
Johannes B. Goll   +27 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Powerful Statistical Inference for Nested Data Using Sufficient Summary Statistics

open access: yesFrontiers in Human Neuroscience, 2018
Hierarchically-organized data arise naturally in many psychology and neuroscience studies. As the standard assumption of independent and identically distributed samples does not hold for such data, two important problems are to accurately estimate group ...
Irene Dowding, Stefan Haufe
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

A cautionary note on the use of the Analysis of Covariance (ANCOVA) in classification designs with and without within-subject factors

open access: yesFrontiers in Psychology, 2015
A number of statistical textbooks recommend using an analysis of covariance (ANCOVA) to control for the effects of extraneous factors that might influence the dependent measure of interest. However, it is not generally recognized that serious problems of
Bruce A Schneider   +2 more
doaj   +1 more source

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