Results 101 to 110 of about 573,105 (295)

OpenLimbTT, a transtibial residual limb shape model for prosthetics simulation and design: creating a statistical anatomic model using sparse data

Data-Centric Engineering
Poor socket fit is the leading cause of prosthetic limb discomfort. However, currently clinicians have limited objective data to support and improve socket design. Finite element analysis predictions might help improve the fit, but this requires internal
Fiona Sunderland, Adam Sobey, Jennifer Bramley, Joshua Steer, Rami Al-Dirini, Cheryl Metcalf, Diana Toderita, Anthony Bull, Ziyun Ding, David Henson, Peter Worsley, Alex Dickinson   +11 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A Bi-atrial Statistical Shape Model and 100 Volumetric Anatomical Models of the Atria

, 2020
This dataset is part of the publication "A bi-atrial statistical shape model for large-scale in silico studies of human atria: model development and application to ECG simulations" (C. Nagel et al., doi:10.1016/j.media.2021.102210).
Loewe, Axel, Nagel, Claudia, Dössel, Olaf, Schuler, Steffen   +3 more
core   +1 more source

Predictive properties of statistical shape models

, 2011
Selected readings in vision and graphics ...
openaire   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Statistical shape modeling of the geometric morphology of the canine femur, tibia, and patella

Frontiers in Veterinary Science
Bone morphometry varies among dogs of different sizes and breeds. Studying these differences may help understand the predisposition of certain breeds for specific orthopedic pathologies.
Jeremy Huart, Antonio Pozzi, Jason Bleedorn, Tung-Wu Lu, Sebastian Knell, Brian Park   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Reliable Procedure for the Construction of a Statistical Shape Model of the Cranial Vault

, 2020
The application of CAx tools in surgery is representing a breakthrough for clinical practice, both in terms of effectiveness and costs. Working directly on the patient’s own diagnostic images, this approach provides powerful tools for pre-operative ...
Servi M., Volpe Y., Volpe, Y., Marzola, A., Servi, M., Marzola A.   +5 more
core   +1 more source

AUTOMATED CONSTRUCTION OF 3D STATISTICAL SHAPE MODELS

Image Analysis & Stereology, 2011
Automated segmentation of medical images is a difficult task because of the complexity of anatomic structures, inter-patient variability, and imperfect image acquisition. Prior knowledge, in the form of pointbased statistical shape models (point distribution models) of a structure of interest can greatly assist segmentation to robustly find the ...
Likar, Boštjan, Pernuš, Franjo, Tomaževič, Dejan, Travnik, Ludvik, Vrtovec, Tomaž   +4 more
openaire   +4 more sources