Results 111 to 120 of about 573,105 (295)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Building method for a statistical shape model by automatically establishing correspondence between a set of two dimensional or three dimensional shapes

, 2005
A method of building a statistical shape model by automatically establishing correspondence between a set of two dimensional shapes or three dimensional shapes, the method comprising: a) determining a parameterisation of each shape, building a ...
Davies, Rhodri, Taylor, Chris; id_orcid, Twining, Carole, Cootes, Timothy; id_orcid   +3 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Development of a Statistical Shape Model and Assessment of Anatomical Shape Variations in the Hemipelvis. [PDF]

J Clin Med, 2023
van Veldhuizen WA, van der Wel H, Kuipers HY, Kraeima J, Ten Duis K, Wolterink JM, de Vries JPM, Schuurmann RCL, IJpma FFA.   +8 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A statistical shape model for deformable surface

, 2010
This short paper presents a deformable surface registration scheme which is based on the statistical shape modelling technique. The method consists of two major processing stages, model building and model fitting.
Shark, Lik, Matuszewski, Bogdan, Quan, Wei   +2 more
core  

The Musculoskeletal Atlas Project Client statistical shape model for femur, which consists of Lagrange piece-wise elements and element nodes.

, 2019
Statistical shape model elements are 2-dimensional, higher-order, quadrilateral or triangular, and consists of fixed element numbering (yellow sections), fixed node distribution (red dots), and shared boundaries (grey lines) with adjacent elements ...
David G. Lloyd (292196), Edin K. Suwarganda (6320861), Trevor N. Savage (4183474), Thor F. Besier (5345978), Laura E. Diamond (6320864), Ju Zhang (281062), Bryce A. Killen (3935096), David J. Saxby (3935093)   +7 more
core   +1 more source

Prediction of the Proximal Humerus Morphology Based on a Statistical Shape Model with Two Parameters: Comparison to Contralateral Registration Method. [PDF]

Bioengineering (Basel), 2023
van Schaardenburgh FE, Nguyen HC, Magré J, Willemsen K, van Rietbergen B, Nijs S.   +5 more
europepmc   +1 more source