Results 141 to 150 of about 573,105 (295)

Exploring shape changes in healthy bone growth through 3D spatiotemporal statistical shape models: A scoping review

Bone Reports
Objective: Analyzing population trends of bone shape variation can provide valuable insights into growth processes. This review aims to overview state-of-the-art spatiotemporal statistical shape modeling techniques, emphasizing their application to 3D ...
Lily E. de Vries, Derek F.R. van Loon, Eline M. van Es, DirkJan H.E.J. Veeger, Joost W. Colaris   +4 more
doaj   +1 more source

A Statistical Shape Model of the Morphological Variation of the Infrarenal Abdominal Aortic Aneurysm Neck. [PDF]

J Clin Med, 2022
van Veldhuizen WA, Schuurmann RCL, IJpma FFA, Kropman RHJ, Antoniou GA, Wolterink JM, de Vries JPM.   +6 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

3-D facial expression representation using B-spline statistical shape model

, 2007
Effective representation and recognition of human faces are essential in a number of applications including human-computer interaction (HCI), bio-metrics or video conferencing. This paper presents initial results obtained for a novel method of 3-D facial
Ait-Boudaoud, Djamel, Shark, Lik, Matuszewski, Bogdan, Quan, Wei   +3 more
core  

Statistical shape model of the talus bone morphology: A comparison between impinged and nonimpinged ankles. [PDF]

J Orthop Res, 2023
Arbabi S, Seevinck P, Weinans H, de Jong PA, Sturkenboom J, van Hamersvelt RW, Foppen W, Arbabi V.   +7 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Virtual reconstruction of orbital floor defects using a statistical shape model. [PDF]

J Anat, 2022
Gass M, Füßinger MA, Metzger MC, Schwarz S, Bähr JD, Brandenburg L, Weingart J, Schlager S.   +7 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

[Rapid femur modeling method based on statistical shape model]. [PDF]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2022
Zhang Z, Chen Z, Zhang Z, Wang C, Jin Z.
europepmc   +1 more source