Results 71 to 80 of about 573,105 (295)
Radiology and Oncology, 2014 Background. With the rapidly increasing application of adaptive radiotherapy, large datasets of organ geometries based on the patient’s anatomy are desired to support clinical application or research work, such as image segmentation, re-planning, and ...
Hu Nan +7 more
doaj +1 more source
Automatic Construction of Statistical Shape Models for Vertebrae [PDF]
, 2011 For segmenting complex structures like vertebrae, a priori knowledge by means of statistical shape models (SSMs) is often incorporated. One of the main challenges using SSMs is the solution of the correspondence problem. In this work we present a generic automated approach for solving the correspondence problem for vertebrae.
Meike Becker +3 more
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A Statistical Shape Model of the Thumb Carpometacarpal Joint
, 2014 The first carpometacarpal (CMC) joint performs a range of dexterous movements, all of which are influenced by the morphology and articulation between the first metacarpal and trapezium bones.
Marco Schneider (526359) +6 more
core +1 more source
A Statistical Model of Spine Shape and Material for Population-Oriented Biomechanical Simulation
IEEE Access, 2021 In population-oriented ergonomics product design and musculoskeletal kinetics analysis, digital spine models of different shape, pose and material property are in great demand.
Xiaobang Sun +6 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
An articulated statistical shape model of the human knee
, 2011 In this work we present an articulated statistical shape model (ASSM) of the human knee. The model incorporates statistical shape variation plus explicit degrees of freedom that model physiological joint motion.
Bindernagel, M. +17 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Statistical Shape Model: comparison between ICP and CPD algorithms on medical applications [PDF]
, 2020 The increasing availability of 3D anatomical models obtained from diagnostic images exploiting Reverse Engineering techniques allows the application of statistical analysis in the quantitative investigation of anatomical shapes variability.
Furferi, Rocco +9 more
core +1 more source