Results 61 to 70 of about 5,906,609 (291)

Statistical significance of variables driving systematic variation

, 2013
There are a number of well-established methods such as principal components analysis (PCA) for automatically capturing systematic variation due to latent variables in large-scale genomic data.
Chung, Neo Christopher, Storey, John D.
core   +1 more source

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

P-values to determine whether natural selection operates in nature: seizing their potential

Revista Mexicana de Biodiversidad, 2018
After 34 years of the development of Lande and Arnold’s (1983) model to quantify natural selection on multivariate quantitative phenotypic traits, researchers still heavily rely on p-values to determine whether natural selection operates or not on ...
Facundo X. Palacio
doaj   +1 more source

The radio/gamma-ray connection in Active Galactic Nuclei in the era of the Fermi Large Area Telescope [PDF]

, 2011
We present a detailed statistical analysis of the correlation between radio and gamma-ray emission of the Active Galactic Nuclei (AGN) detected by Fermi during its first year of operation, with the largest datasets ever used for this purpose. We use both
A. Allafort, A. Bouvier, A. Brez, A. Cannon, A. Chekhtman, A. Makeev, A. Morselli, A. Okumura, A. P. Waite, A. Readhead, A. Reimer, A. S. Johnson, A. Tramacere, A. W. Borgland, Abdo, Abdo, Abdo, Abdo, Abdo, Abdo, Aharonian, Akujor, B. Berenji, B. L. Winer, B. Lott, Baars, C. C. Cheung, C. Cecchi, C. D. Dermer, C. Favuzzi, C. Monte, C. Sgrò, Condon, D. Bastieri, D. Dumora, D. F. Torres, D. Gasparrini, D. Hadasch, D. J. Suson, D. J. Thompson, D. Paneque, Danforth, Dondi, E. Angelakis, E. Bonamente, E. Cavazzuti, E. Charles, E. D. Bloom, E. do Couto e Silva, E. Hays, E. J. Siskind, E. Nuss, E. Orlando, E. Troja, Elvis, F. de Palma, F. Gargano, F. Giordano, F. Longo, F. Loparco, F. Piron, G. A. Caliandro, G. B. Taylor, G. Barbiellini, G. Godfrey, G. Jóhannesson, G. Spandre, G. Tosti, G. Vianello, Giroletti, H. F.-W. Sadrozinski, H. Katagiri, H. Takahashi, Healey, Healey, Helmboldt, I. A. Grenier, I. V. Moskalenko, Isobe, J. B. Thayer, J. Ballet, J. Bregeon, J. Cohen-Tanugi, J. D. Scargle, J. E. McEnery, J. F. Ormes, J. G. Thayer, J. Kataoka, J. Knödlseder, J. L. Richards, J. Lande, J. M. Casandjian, J. Mehault, J. P. Norris, J. Vandenbroucke, K. S. Wood, Komatsu, Kovalev, L. Baldini, L. Escande, L. Fuhrmann, Linford, M. Ackermann, M. Ajello, M. Axelsson, M. Brigida, M. E. Monzani, M. Frailis, M. Giroletti, M. Hayashida, M. Kuss, M. N. Lovellette, M. N. Mazziotta, M. Naumann-Godo, M. Ozaki, M. Pepe, M. Pesce-Rollins, M. Pierbattista, M. Razzano, M. S. Strickman, M. Ziegler, Mahony, Marchã, Mukherjee, Mücke, N. Gehrels, N. Giglietto, N. Omodei, Nagar, O. Reimer, P. A. Caraveo, P. Bruel, P. D. Smith, P. F. Michelson, P. Fortin, P. Fusco, P. Giommi, P. Grandi, P. L. Nolan, P. Lubrano, P. S. Drell, P. Spinelli, P. Wang, Padovani, Pavlidou, R. A. Cameron, R. Bellazzini, R. Buehler, R. Claus, R. D. Blandford, R. Dubois, R. W. Romani, Richards, S. Buson, S. Ciprini, S. Cutini, S. E. Healey, S. Guiriec, S. J. Fegan, S. Murgia, S. Nishino, S. Rainò, S.-H. Lee, T. A. Porter, T. Glanzman, T. Kamae, T. Mizuno, T. Ohsugi, T. Tanaka, Taylor, Tingay, Unger, V. Pavlidou, V. Pelassa, V. Vitale, W. B. Focke, W. Max-Moerbeck, Y. Fukazawa, Z. Yang   +178 more
core   +4 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Redefine statistical significance [PDF]

, 2018
We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new ...
Benjamin, Daniel J., Camerer, Colin
core  

Physics of Large Deviation

, 2012
A large deviation function mathematically characterizes the statistical property of atypical events. Recently, in non-equilibrium statistical mechanics, large deviation functions have been used to describe universal laws such as the fluctuation theorem ...
Sasa, Shin-ichi
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

COMMENT ON THE KAMIOKANDE ATMOSPHERIC NEUTRINO DEFICIT [PDF]

, 1995
I describe an attempt to understand the significance of the atmospheric neutrino deficit observed by the Kamiokande neutrino detector. In particular, I am concerned with the statistical significance quoted for the zenith-angle dependence of the deficit ...
Saltzberg, David
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source