Results 71 to 80 of about 3,920,331 (369)

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

Investigation of comorbidities of COVID-19 patients with hepatosteatosis using latent class analysis

Frontiers in Public Health, 2022
IntroductionCoronavirus Disease 2019 (COVID-19) disease first appeared in Wuhan, China in December 2019. Subsequently, the pandemic spread rapidly throughout the entire world. The number of people who died from COVID-19 is rising daily due to the growing
Ozge Pasin, Sirin Cetin, Ahmet Turan Kaya   +2 more
doaj   +1 more source

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

Nucleic Acids Res., 2018
The GWAS Catalog delivers a high-quality curated collection of all published genome-wide association studies enabling investigations to identify causal variants, understand disease mechanisms, and establish targets for novel therapies.
A. Buniello, J. MacArthur, M. Cerezo, Laura W. Harris, J. Hayhurst, Cinzia Malangone, A. McMahon, Joannella Morales, Edward Mountjoy, E. Sollis, D. Suveges, Olga Vrousgou, P. Whetzel, R. Amode, Jose A. Guillen, H. Riat, S. Trevanion, Peggy Hall, Heather Junkins, P. Flicek, Tony Burdett, L. Hindorff, Fiona Cunningham, H. Parkinson   +23 more
semanticscholar   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Multivariate Statistical Analysis Applied to Water Quality of a Tropical Coastal Lagoon, Cartagena, Colombian Caribbean

Indonesian Journal of Chemistry, 2019
Coastal lagoons are one of the most threatened ecosystems in the world, because of population growth, habitat destruction, pollution, wastewater, overexploitation and invasive species which are the main causes of their degradation.
Ildefonso Baldiris-Navarro, Juan Carlos Acosta-Jimenez, Angel Dario Gonzalez-Delgado, Alvaro Realpe-Jimenez, Juan Gabriel Fajardo-Cuadro   +4 more
doaj   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

ONLINE STATISTICS SYSTEM FOR PARTICIPANTS IN THE DISCORD MESSENGER USING PYTHON AND POSTGRESQL

International Journal of Advanced Studies, 2022
The relevance of the topic under consideration is since in one of the Discord channel communities there was a need to collect the activity of channel members for a certain time and duration.
Roman R. Krapivin, Linar M. Akhmetov, Marat R. Khamidullin, Gulnara A. Gareeva   +3 more
doaj   +1 more source

Introduction [PDF]

Statistical Science 2011, Vol. 26, No. 2, 161-161, 2011
The Statistics Consortium at the University of Maryland, College Park, hosted a two-day workshop on Bayesian Methods that Frequentists Should Know during April 30--May 1, 2008. The event was co-sponsored by the Institute of Mathematical Statistics (IMS), Office of Research and Methodology, National Center for Health Statistics, Survey Research Methods ...
arxiv   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source