Results 81 to 90 of about 890,957 (263)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Integrating word status for joint detection of sentiment and aspect in reviews

, 2019
A crucial task in sentiment analysis is aspect detection: the step of selecting the aspects on which opinions are expressed. This step anticipates the step of determining whether the opinions on aspects are positive or negative.
Methodology and statistics for the behavioural and social sciences, Bagheri, A.   +1 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Dual Imputation Strategies for Analyzing Incomplete Data

, 2012
Missing data are an important practical problem in many applications of statistics, including social and behavioral sciences. The older and simple strategy is to choose ad-hoc methods (e.g.
Methodology and statistics for the behavioural and social sciences, Jolani, S., Afd methoden en statistieken   +2 more
core  

Possible Solution to Publication Bias Through Bayesian Statistics, Including Proper Null Hypothesis Testing

, 2015
The present paper argues that an important cause of publication bias resides in traditional frequentist statistics forcing binary decisions. An alternative approach through Bayesian statistics provides various degrees of support for any hypothesis ...
Konijn, E.A.; id_orcid, Methodology and statistics for the behavioural and social sciences, van de Schoot, Rens, Van de Schoot, R., Leerstoel Hoijtink, Konijn, Elly A., Konijn, E.A., Ferguson, C.J, Winter, S., Winter, Sonja D., Ferguson, Christopher J.   +10 more
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

October Household Survey, 1996

, 1996
During October 1996, under the Census 1996 motto "Count us in", a hundred thousand employees of Statistics South Africa fanned out across the cities, towns, townships, informal settlements, villages, farms and rural areas of the country.
Statistics South Africa
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

qgraph: Network Visualizations of Relationships in Psychometric Data

, 2012
We present the qgraph package for R, which provides an interface to visualize data through network modeling techniques. For instance, a correlation matrix can be represented as a network in which each variable is a node and each correlation an edge; by ...
Denny Borsboom, Borsboom, Denny, Angelique O. J. Cramer, Waldorp, Lourens J., Epskamp, S., Waldorp, L.J., Verena D. Schmittmann, Schmittmann, Verena D., Schmittmann, V.D., Cramer, A.O.J., Sacha Epskamp, Cramer, Angélique O. J., Borsboom, D., Epskamp, Sacha, Cramer, Angélique O.J., Lourens J. Waldorp   +15 more
core   +1 more source