Results 31 to 40 of about 544,329 (286)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Rotation-invariance is essential for accurate detection of spatially variable genes in spatial transcriptomics

Nature Communications
In spatial transcriptomics, tissue samples are randomly positioned. Rotation-sensitive methods can lead to unreliable spatially variable gene (SVG) detection.
Haohao Su, Yuehua Cui
doaj   +1 more source

Lack of Effect of H2-Receptor Antagonists and Antacids on the Gastric and Duodenal Gastrin-, Somatostatin- and Serotonin-Producing Cells in Patients with Acid Peptic Disorders

Canadian Journal of Gastroenterology, 1996
Standard therapeutic approaches to acid peptic disorders have dealt with neutralizing or inhibiting aggressive factors and/or bolstering defensive factors.
WR Yacoub, ABR Thomson, P Hooper, LD Jewell   +3 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

STANCE: a unified statistical model to detect cell-type-specific spatially variable genes in spatial transcriptomics

Nature Communications
One of the major challenges in spatial transcriptomics is to detect spatially variable genes (SVGs), whose expression patterns are non-random across tissue locations.
Haohao Su, Yuesong Wu, Bin Chen, Yuehua Cui   +3 more
doaj   +1 more source

Positive Correlation between Normal Serum Gastrin Concentrations and Antral and Duodenal G Cells

Canadian Journal of Gastroenterology, 1994
It is controversial whether there is a correlation between serum gastrin concentrations and the density of G cells in the antral or duodenal mucosa. In this study, endoscopically obtained antral and duodenal biopsies were stained immunocytochemically for
WR Yacoub, ABR Thomson, RW Sherbaniuk, P Hooper, LD Jewell   +4 more
doaj   +1 more source

Correction The probabilities of large deviations for a certain class of statistics associated with multinomial distributions [PDF]

, 2021
Sherzod M. Mirakhmedov
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Estimation of Threshold Effect of Kenyan Shilling Exchange Rate on Rwandan Economy: A Semiparametric Model Approach

Journal of Applied Mathematics
The exchange rate is an important variable in international trade which is used as a parameter to determine a country’s international competitiveness and indicates the position of the country’s economy. A change in the exchange rate of the Kenya shilling
Charline Uwilingiyimana, Amour Gbaguidi Amoussou, Faustin Habyarimana, Carlos Ogouyandjou   +3 more
doaj   +1 more source

The Holling Type II Population Model Subjected to Rapid Random Attacks of Predator

Journal of Applied Mathematics, 2018
We present the analysis of a mathematical model of the dynamics of interacting predator and prey populations with the Holling type random trophic function under the assumption of random time interval passage between predator attacks on prey. We propose a
Jevgeņijs Carkovs, Jolanta Goldšteine, Kārlis Šadurskis   +2 more
doaj   +1 more source